Evidence map›Paper›PMID 34054874›Full record

ArticleFrontiers in immunology2021

Cyclic Helix B Peptide Prolongs Skin Allograft Survival

Long Zheng, Xuanchuan Wang, Linkun Hu, Wenjun Gao, Weitao Zhang, Xuepeng Zhang, Chao Hu, Ruiming Rong, Cheng Yang, Dong Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Long ZhengDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xuanchuan WangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Linkun HuDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wenjun GaoDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Weitao ZhangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xuepeng ZhangDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Chao HuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Ruiming RongDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Cheng YangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Dong ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Sun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNFudan University · CNSoochow University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-mediated rejection (AMR) represents a major cause of allograft dysfunction and results in allograft failure in solid organ transplantation. Cyclic helix B peptide (CHBP) is a novel erythropoietin-derived peptide that ameliorated renal allograft rejection in a renal transplantation model. However, its effect on AMR remains unknown. This study aimed to investigate the effect of CHBP on AMR using a secondary allogeneic skin transplantation model, which was created by transplanting skin from BALB/c mice to C57BL/6 mice with or without CHBP treatment. A secondary syngeneic skin transplantation model, involving transplantation from C57BL/6 mice to C57BL/6 mice, was also created to act as a control. Skin graft rejection, CD19

Indexed as

AllograftsAnimalsB-LymphocytesDisease Models, AnimalErythropoietinGerminal CenterGraft RejectionGraft SurvivalImmunohistochemistryImmunophenotypingIsoantibodiesMaleMicePeptide FragmentsPeptides, CyclicPlasma CellsErythropoietinglutaminyl-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serineIsoantibodiesPeptide FragmentsPeptides, Cyclicantibody-mediated rejectioncyclic helix B peptidedonor specific antibodiesgerminal center B cellsplasma cellsTfh cells

Identifiers

PMID34054874
PMCPMC8149941
OpenAlexW3162972058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.