Evidence map›Paper›PMID 34054836›Full record

ArticleFrontiers in immunology2021

Interferon Gamma Induces the Increase of Cell-Surface Markers (CD80/86, CD83 and MHC-II) in Splenocytes From Atlantic Salmon.

Byron Morales-Lange, Felipe Ramírez-Cepeda, Paulina Schmitt, Fanny Guzmán, Leidy Lagos, Margareth Øverland, Valentina Wong-Benito, Mónica Imarai, Derie Fuentes, Sebastián Boltaña and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. The M1/M2 Test System for Determining Macrophage Phenotypes.International journal of molecular sciences · 2026
    Review
  3. Frontiers in immunology · 2026
    Article
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  12. Why DoesFrontiers in immunology · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Byron Morales-LangeGrupo de Marcadores Inmunológicos en Organismos Acuáticos, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Felipe Ramírez-CepedaGrupo de Marcadores Inmunológicos en Organismos Acuáticos, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Paulina SchmittGrupo de Marcadores Inmunológicos en Organismos Acuáticos, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Fanny GuzmánLaboratorio de Síntesis de Péptidos, Núcleo Biotecnología de Curauma, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Leidy LagosDepartment of Animal and Aquaculture Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway.
Margareth ØverlandDepartment of Animal and Aquaculture Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway.
Valentina Wong-BenitoLaboratorio de Inmunología, Departamento de Biología, Centro de Biotecnología Acuícola, Universidad de Santiago de Chile, Santiago, Chile.
Mónica ImaraiLaboratorio de Inmunología, Departamento de Biología, Centro de Biotecnología Acuícola, Universidad de Santiago de Chile, Santiago, Chile.
Derie FuentesAquaculture and Marine Ecosystems, Center for Systems Biotechnology, Fraunhofer Chile Research, Santiago, Chile.
Sebastián BoltañaDepartment of Oceanography, University of Concepción, Concepción, Chile.
Javier AlcaínoAquaAdvise-Fundación Chile, Puerto Montt, Chile.
Carlos SotoSalmones Camanchaca, Puerto Montt, Chile.
Luis MercadoGrupo de Marcadores Inmunológicos en Organismos Acuáticos, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Pontificia Universidad Católica de Valparaíso · CLNorwegian University of Life Sciences · NOUniversidad de Santiago de Chile · CLFraunhofer Chile Research Foundation · CLFundación Chile · CLInstituto Tecnológico del Salmón · CLUniversity of Concepción · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type II interferon gamma (IFNγ) is a pleiotropic cytokine capable of modulating the innate and adaptive immune responses which has been widely characterized in several teleost families. In fish, IFNγ stimulates the expression of cytokines and chemokines associated with the pro-inflammatory response and enhances the production of nitrogen and oxygen reactive species in phagocytic cells. This work studied the effect of IFNγ on the expression of cell-surface markers on splenocytes of Atlantic salmon (

Indexed as

AnimalsAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenBiomarkersCD83 AntigenFish DiseasesHistocompatibility Antigens Class IIImmunoglobulinsInterferon-gammaLeukocytes, MononuclearMembrane GlycoproteinsPiscirickettsiaPiscirickettsiaceae InfectionsSalmo salarAntigens, CDB7-1 AntigenB7-2 AntigenBiomarkersCD83 AntigenHistocompatibility Antigens Class IIImmunoglobulinsInterferon-gammaMembrane GlycoproteinsTranscription Factorsfish dendritic cellsfish interferon-gammafish phenotypic markersfish splenocytesfish zbtb46Salmo salar

Identifiers

PMID34054836
PMCPMC8155612
OpenAlexW3161708058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.