Evidence map›Paper›PMID 34054815›Full record

ArticleFrontiers in immunology2021

Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in the Absence of Nitric Oxide.

Melanie C McKell, Rebecca R Crowther, Stephanie M Schmidt, Michelle C Robillard, Rachel Cantrell, Maria A Lehn, Edith M Janssen, Joseph E Qualls

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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  15. Metabolic flux reprogramming inFrontiers in microbiology · 2023
    Article
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  18. Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Melanie C McKellDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Rebecca R CrowtherDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Stephanie M SchmidtDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Michelle C RobillardDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Rachel CantrellDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Maria A LehnDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Edith M JanssenDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Joseph E QuallsDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
University of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · US

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
L-citrulline and anti-tuberculosis host defenseR01AI116668 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI QUALLS, JOSEPH E · 2016 to 2020
$1.9M
Pathogenesis and therapeutic targeting of immune disordersT32AI118697 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2016 to 2020
$683k
NIAID NIH HHS R01 AI116668NIAID NIH HHS T32 AI118697NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens.

Indexed as

Dietary SupplementsAnimalsArginineArgininosuccinate LyaseArgininosuccinate SynthaseCell SurvivalDisease Models, AnimalHumansMacrophage ActivationMacrophagesMiceMice, KnockoutMycobacterium tuberculosisNitric OxidePrimary Cell CultureRAW 264.7 CellsArginineArgininosuccinate LyaseArgininosuccinate SynthaseNitric Oxideargininecitrullineglycolysismacrophagetuberculosis

Identifiers

PMID34054815
PMCPMC8160513
OpenAlexW3161511065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.