Evidence map›Paper›PMID 34054804›Full record

ArticleFrontiers in immunology2021

Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations.

Titi Chen, Qi Cao, Ruifeng Wang, Guoping Zheng, Farhana Azmi, Jeffery Wang, Vincent W Lee, Yuan Min Wang, Hong Yu, Manish Patel and 5 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Titi ChenSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Qi CaoSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Ruifeng WangCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
Guoping ZhengSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Farhana AzmiSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Jeffery WangSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Vincent W LeeSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Yuan Min WangCentre for Kidney Research, Children's Hospital at Westmead, Sydney, NSW, Australia.
Hong YuCentre for Transplant and Renal Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
Manish PatelSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Chow Heok P'ngDepartment of Anatomical Pathology, Westmead Hospital, Westmead, NSW, Australia.
Stephen I AlexanderCentre for Kidney Research, Children's Hospital at Westmead, Sydney, NSW, Australia.
Natasha M RogersSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Yiping WangSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
David C H HarrisSchool of Medicine, The University of Sydney, Camperdown, NSW, Australia.
Westmead Institute for Medical Research · AUThe University of Sydney · AUChildren's Hospital at Westmead · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: cDC1 is a subset of conventional DCs, whose most recognized function is cross-presentation to CD8 Methods: We analyzed 135 kidney biopsies samples. Kidney diseases included: acute tubular necrosis (ATN), acute interstitial nephritis (AIN), proliferative glomerulonephritis (GN) (IgA nephropathy, lupus nephritis, pauci-immune GN, anti-GBM disease), non-proliferative GN (minimal change disease, membranous nephropathy) and diabetic nephropathy. Indirect immunofluorescence staining was used to quantify cDC1s, CD1c Results: cDC1s were rarely present in normal kidneys. Their number increased significantly in ATN and proliferative GN, proportionally much more than CD1c Conclusions: cDC1 number correlated with various clinic-pathological features and prognosis reflecting a possible role in these conditions. Their association with CD8

Indexed as

Cross-PrimingAdultAgedBiopsyCase-Control StudiesCD8-Positive T-LymphocytesDendritic CellsFemaleFibrosisFluorescent Antibody TechniqueHumansKidneyKidney DiseasesMaleMiddle AgedPhenotypeacute tubular necrosisCD141+ DCsconventional DCscrescentdendritic cellsglomerulonephritisinterstitial fibrosis

Identifiers

PMID34054804
PMCPMC8149958
OpenAlexW3160771108

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.