Evidence map›Paper›PMID 34054728›Full record

ArticleFrontiers in endocrinology2021

Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study.

Qian Zhang, Xiaoqian Ma, Jie Xing, Haiyun Shi, Runkuan Yang, Yue Jiao, Shuohua Chen, Shouling Wu, Shutian Zhang, Xiujing Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  10. Obesity-Associated Hyperuricemia in Female Mice: A Reevaluation.Gout, urate, and crystal deposition disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Qian ZhangDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Xiaoqian MaDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Jie XingDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Haiyun ShiDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Runkuan YangDepartment of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Yue JiaoDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Shuohua ChenDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Shouling WuDepartment of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Shutian ZhangDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Xiujing SunDepartment of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.
Beijing Friendship Hospital · CNNational Clinical Research Center for Digestive Diseases · CNOslo University Hospital · NOKailuan General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies. Patients and methods: This study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively. Results: By adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively. Conclusion: The findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered.

Indexed as

BiomarkersChinaFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityPrognosisProspective StudiesRisk FactorsUric AcidBiomarkersUric Acidbody mass indexmediation analysismetabolic syndromenonalcoholic fatty liver diseaseobesityserum uric acid

Identifiers

PMID34054728
PMCPMC8158156
OpenAlexW3161346565

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.