Evidence map›Paper›PMID 34054402›Full record

ArticleFrontiers in neuroscience2021

Gender Matters: Nonlinear Relationships Between Heart Rate Variability and Depression and Positive Affect.

Derek P Spangler, Emily J Dunn, Amelia Aldao, Nicole R Feeling, Matthew L Free, Brandon L Gillie, Michael W Vasey, DeWayne P Williams, Julian Koenig, Julian F Thayer

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Adjusting Autonomic Physiology with Diet and Minerals to Improve Health.Integrative medicine (Encinitas, Calif.) · 2026
    Review
  5. Article
  6. Article
  7. Are the ways women cope with stressors related to their health behaviors over time?Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Derek P SpanglerDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, United States.
Emily J DunnDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Amelia AldaoDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Nicole R FeelingDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Matthew L FreeAnxiety and Behavioral Health Services, Worthington, OH, United States.
Brandon L GillieUniversity of Pittsburgh Medical Center Sports Medicine Concussion Program, Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Michael W VaseyDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
DeWayne P WilliamsDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Julian KoenigSection for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Heidelberg University, Heidelberg, Germany.
Julian F ThayerDepartment of Psychology, The Ohio State University, Columbus, OH, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vagally mediated heart rate variability (vmHRV), a measure of the parasympathetic nervous system's control over the heart, is often negatively related to maladaptive emotional outcomes. Recent work suggests that quadratic relationships involving these factors may be present; however, research has not investigated gender differences in these nonlinear functions. To address this gap, the current study tested for quadratic relationships between resting vmHRV and depression and positive affect while investigating gender differences in these relationships. Significant quadratic effects were found between resting vmHRV and reports of both depression symptoms and positive affect in women but not men. Specifically, the lowest levels of depression and the highest levels of positive affect were found at moderate vmHRV in women. These results suggest that examinations of vmHRV's nonlinear associations require the consideration of gender. Our findings are interpreted based on proposed differential neuropsychological mechanisms of vmHRV in men versus women.

Indexed as

autonomic nervous systemdepressionemotiongendergender differencesheart rate variabilitynonlinearpositive affect

Identifiers

PMID34054402
PMCPMC8155374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.