Evidence map›Paper›PMID 34054153›Full record

ArticleTetrahedron letters2021

Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.

Caroline G Webster, Hyeri Park, Amanda F Ennis, Jiyong Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Total synthesis of grayanane natural products.Beilstein journal of organic chemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caroline G Webster *Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Hyeri Park *Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Amanda F EnnisDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Jiyong HongDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Funding

Pharmacological Sciences Training ProgramT32GM007105 · NIGMS · DUKE UNIVERSITY · PI KUHN, CYNTHIA M · 1985 to 2019
$9.0M
Pharmacological Sciences Training ProgramT32GM133352 · NIGMS · DUKE UNIVERSITY · PI Cynthia M Kuhn, David M MacAlpine · 2020 to 2026
$3.8M
NIGMS NIH HHS T32 GM007105NIGMS NIH HHS T32 GM133352
6 · The paper itself

Abstract

Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-catalyzed Conia-ene cyclization and the Mn(III)-mediated radical cyclization of alkynyl ketones for the synthesis of the bicyclo[3.2.1]octane fragment of rhodojaponin III. These strategies will be applicable in the synthesis of rhodojaponin III and analogs for future biological studies.

Indexed as

Antinociceptive activityBicyclo[3.2.1]octaneGrayanane diterpenoidRadical cyclizationRhodojaponin

Identifiers

PMID34054153
PMCPMC8153367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.