ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Genetic underpinnings of sociability in the general population.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Shared genetic architecture across social disconnection, social disadvantage, and psychiatric and neurodevelopmental traits.European archives of psychiatry and clinical neuroscience · 2026Article
- Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.Nature human behaviour · 2026Article
- Circadian rhythm lncRNABiochemistry and biophysics reports · 2026Article
- Sociability and whole-brain resting-state connectivity.Scientific reports · 2026Article
- Inference of Autism Risk Genes Through Comparative Sociogenomics and Molecular Network Analysis.Genes · 2026Article
- Sociability is a Multidimensional Trait in Drosophila melanogaster.Behavior genetics · 2026Article
- Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population.Translational psychiatry · 2026Article
- Personality Genomics.Annual review of psychology · 2026Review
- Shared genetic architecture between psychiatric and insulin-related traits in the general population.Neuroscience applied · 2026Article
- Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its Diseases.Brain sciences · 2025Review
- Genetic variation influences food-sharing sociability in honey bees.PLoS biology · 2025Article
- Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?European archives of psychiatry and clinical neuroscience · 2025Review
- Rare variants inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Shared genetics and causal relationship between sociability and the brain's default mode network.Psychological medicine · 2025Article
- Social isolation and poor mental health in young people: testing genetic and environmental influences in a longitudinal cohort study.European child & adolescent psychiatry · 2025Article
- Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study.European archives of psychiatry and clinical neuroscience · 2025Article
- Assessing genetic conservation of human sociability-linked genes in C. elegans.Behavior genetics · 2025Article
- Unveiling the interplay of medical professionalism, mental well-being and coping in medical students: a qualitative phenomenological study.BMC medical education · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Levels of sociability are continuously distributed in the general population, and decreased sociability represents an early manifestation of several brain disorders. Here, we investigated the genetic underpinnings of sociability in the population. We performed a genome-wide association study (GWAS) of a sociability score based on four social functioning-related self-report questions from 342,461 adults in the UK Biobank. Subsequently we performed gene-wide and functional follow-up analyses. Robustness analyses were performed in the form of GWAS split-half validation analyses, as well as analyses excluding neuropsychiatric cases. Using genetic correlation analyses as well as polygenic risk score analyses we investigated genetic links of our sociability score to brain disorders and social behavior outcomes. Individuals with autism spectrum disorders, bipolar disorder, depression, and schizophrenia had a lower sociability score. The score was significantly heritable (SNP h
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