Evidence map›Paper›PMID 34054110›Full record

ReviewCurrent opinion in neurology2021

Data-driven approaches to neuroimaging biomarkers for neurological and psychiatric disorders: emerging approaches and examples.

Vince D Calhoun, Godfrey D Pearlson, Jing Sui

Abstract readReview
In one paragraph

Review in Current opinion in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia.
Godfrey D PearlsonDepartment of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA.
Jing SuiTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Data driven dynamic activity/connectivity methods for early detection of Alzheimer’sR01AG073949 · NIA · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2021 to 2025
$3.7M
Flexible multivariate models for linking multi-scale connectome and genome data in Alzheimer's disease and related disordersRF1AG063153 · NIA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2020
$3.5M
Data-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivityR01MH123610 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2021 to 2025
$3.1M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Data-driven approaches to identify biomarkers from multimodal imaging big dataR01MH117107 · NIMH · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D · 2019 to 2022
$1.6M
Generalizing and Standardizing fMRI Tools for Differentiating Mental Illnesses and Predicting Medication-Class Response in PatientsR41MH122201 · NIMH · ADVANCED BIOMEDICAL INFORMATICS GROUP · PI BOCKHOLT, HENRY JEREMY, CALHOUN, VINCE D · 2020 to 2021
$889k
NCATS NIH HHS UL1 TR001863NIA NIH HHS R01 AG073949NIA NIH HHS RF1 AG063153NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIMH NIH HHS R01 MH117107NIMH NIH HHS R01 MH118695NIMH NIH HHS R01 MH123610NIMH NIH HHS R41 MH122201
6 · The paper itself

Abstract

purpose of reviewThe 'holy grail' of clinical applications of neuroimaging to neurological and psychiatric disorders via personalized biomarkers has remained mostly elusive, despite considerable effort. However, there are many reasons to continue to be hopeful, as the field has made remarkable advances over the past few years, fueled by a variety of converging technical and data developments. RECENT

findingsWe discuss a number of advances that are accelerating the push for neuroimaging biomarkers including the advent of the 'neuroscience big data' era, biomarker data competitions, the development of more sophisticated algorithms including 'guided' data-driven approaches that facilitate automation of network-based analyses, dynamic connectivity, and deep learning. Another key advance includes multimodal data fusion approaches which can provide convergent and complementary evidence pointing to possible mechanisms as well as increase predictive accuracy. SUMMARY: The search for clinically relevant neuroimaging biomarkers for neurological and psychiatric disorders is rapidly accelerating. Here, we highlight some of these aspects, provide recent examples from studies in our group, and link to other ongoing work in the field. It is critical that access and use of these advanced approaches becomes mainstream, this will help propel the community forward and facilitate the production of robust and replicable neuroimaging biomarkers.

Indexed as

Mental DisordersNeuroimagingBiomarkersHumansBiomarkers

Identifiers

PMID34054110
PMCPMC8263510

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.