Evidence map›Paper›PMID 34053991›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.

Ken Murakami, Yuuta Yamaguchi, Yuko Kida, Yoichiro Morikawa, Hidetoshi Ujiie, Hiroyuki Sugahara, Yasuhito Nannya, Seishi Ogawa, Yuzuru Kanakura

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ken MurakamiDepartment of Hematology, Sumitomo Hospital, Japan.
Yuuta YamaguchiDepartment of Hematology, Sumitomo Hospital, Japan.
Yuko KidaDepartment of Hematology, Sumitomo Hospital, Japan.
Yoichiro MorikawaDepartment of Hematology, Sumitomo Hospital, Japan.
Hidetoshi UjiieDepartment of Hematology, Sumitomo Hospital, Japan.
Hiroyuki SugaharaDepartment of Hematology, Sumitomo Hospital, Japan.
Yasuhito NannyaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.
Yuzuru KanakuraDepartment of Hematology, Sumitomo Hospital, Japan.
Sumitomo Hospital · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital mutations of the Wilms' tumor 1 (WT1) gene can lead to various abnormalities, including renal/gonadal developmental disorders and cardiac malformations. Although there have been many reports of somatic WT1 mutations in patients with acute myeloid leukemia and myelodysplastic syndrome, congenital WT1 mutations have not been reported in hematological disorders. We herein report a patient with early-onset clonal cytopenia of undetermined significance that was associated with a congenital mutation of WT1 and an acquired mutation of DNMT3A [encoding DNA (cytosine-5)-methyltransferase 3A].

Indexed as

Clonal HematopoiesisKidney NeoplasmsWilms TumorDNA Methyltransferase 3AGenes, Wilms TumorHumansMutationWT1 ProteinsDNA Methyltransferase 3ADNMT3A protein, humanWT1 ProteinsCCUSclonal cytopenias of undetermined significancegermline WT1 mutationMeacham syndrome

Identifiers

PMID34053991
PMCPMC8710374
OpenAlexW3164964295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.