Evidence map›Paper›PMID 34053940›Full record

ArticleBiomolecules & therapeutics2021

Structural Requirements for Modulating 4-Benzylpiperidine Carboxamides from Serotonin/Norepinephrine Reuptake Inhibitors to Triple Reuptake Inhibitors.

Suresh Paudel, Eunae Kim, Anlin Zhu, Srijan Acharya, Xiao Min, Seung Hoon Cheon, Kyeong-Man Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Suresh PaudelCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Eunae KimCollege of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Anlin ZhuCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Srijan AcharyaCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Xiao MinCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Seung Hoon CheonCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Kyeong-Man KimCollege of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.
Chonnam National University · KRChosun University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

8K: and a serotonin/norepinephrine reuptake inhibitor. 7J: showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket. The compound. 8K: bound tightly to the binding pocket of all three monoamine reuptake transporters; however. 7J: showed poor docking with DAT. Co-expression of DAT with the dopamine D 8F: , which is one of the compounds with good inhibitory activity on DAT, blocked DAT-induced inhibition of D

Indexed as

4-Benzylpiperidine carboxamidesDockingDopamine DNorepinephrine reuptake inhibitorSerotonin reuptake inhibitorTriple reuptake inhibitor

Identifiers

PMID34053940
PMCPMC8255136
OpenAlexW3165807521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.