Evidence map›Paper›PMID 34053679›Full record

ArticleTrends in neurosciences2021

Membrane molecules for mood.

David A Slattery, John F Cryan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

David A SlatteryDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt am Main, Germany. Electronic address: David.Slattery@kgu.de.
John F CryanDepartment of Anatomy & Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
APC Microbiome Institute · IEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

Indexed as

Brain-Derived Neurotrophic FactorReceptor, trkBAntidepressive AgentsHumansNeuronal PlasticitySignal TransductionAntidepressive AgentsBrain-Derived Neurotrophic FactorReceptor, trkBantidepressantBDNFdepressionplasticity

Identifiers

PMID34053679
OpenAlexW3165805444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.