Evidence map›Paper›PMID 34053382›Full record

SynthesisWomen's health (London, England)

A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project.

Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri and 12 more

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05622955 (A Novel Approach to Endometriosis Treatment), which is not on this map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05622955 nacompletednot on this map

A Novel Approach to Endometriosis Treatment: Piloting an Interdisciplinary Group Care Model

TypeinterventionalSponsorWashington University School of MedicineRan2023 to 2025Enrolled35ConditionsEndometriosis, Pelvic PainArmsPeer Empowered Endometriosis Pain Support (PEEPS)
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  9. Observational
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  12. Clinical characterization of endometriosis phenotypes.Archives of gynecology and obstetrics · 2025
    Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 5 countries.

Gayathri DelanerolleOxford Brain Health Clinical Trials Unit, University of Oxford, Oxford, UK.ORCID 0000-0002-9628-9245
Rema RamakrishnanNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Dharani HapangamaUniversity of Liverpool, Liverpool, UK.
Yutian ZengSouthern University of Science and Technology, Shenzhen, China.
Ashish ShettyUniversity College London Hospitals NHS Foundation Trust, London, UK.
Sohier ElneilUniversity College London Hospitals NHS Foundation Trust, London, UK.
Sam ChongUniversity College London Hospitals NHS Foundation Trust, London, UK.
Martin HirschUniversity College London Hospitals NHS Foundation Trust, London, UK.
Molola OyewoleUniversity College London Hospitals NHS Foundation Trust, London, UK.
Peter PhiriSouthern Health NHS Foundation Trust, Southampton, UK.
Kathryn ElliotSouthern Health NHS Foundation Trust, Southampton, UK.
Trusha KothariLiverpool Women's NHS Foundation, Liverpool, UK.
Bryony RogersUniversity of Liverpool, Liverpool, UK.
Natasha SandleOxford Brain Health Clinical Trials Unit, University of Oxford, Oxford, UK.
Nyla HaqueOxford Brain Health Clinical Trials Unit, University of Oxford, Oxford, UK.
Nicola PluchinoDivisions of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.
Martin SilemUniversity Medical Center Freiburg, Freiburg, Germany.
Rebecca O'HaraRobinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
M Louise HullRobinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.
Kingshuk MajumderManchester University NHS Foundation Trust, Manchester, UK.
Jian Qing ShiSouthern University of Science and Technology, Shenzhen, China.
Vanessa RaymontOxford Brain Health Clinical Trials Unit, University of Oxford, Oxford, UK.
University College London Hospitals NHS Foundation Trust · GBUniversity of Oxford · GBUniversity of Liverpool · GBSouthern Health NHS Foundation Trust · GBSouthern University of Science and Technology · CNThe University of Adelaide · AUManchester University NHS Foundation Trust · GBUniversity Hospital of Geneva · CHUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is important to evaluate sequalae for complex chronic health conditions such as endometriosis and mental health disorders. Endometriosis impacts 1 in 10 women. Mental health outcomes can be a primary determinant in many physical health conditions although this is an area not well researched particularly in women's health. This has been problematic for endometriosis patients in particular, who report mental health issues as well as other key comorbidities such as chronic pelvic pain and infertility. This could be partly due to the complexities associated with comprehensively exploring overlaps between physical and mental health disorders in the presence of multiple comorbidities and their potential mechanistic relationship.

methodsIn this evidence synthesis, a systematic methodology and mixed-methods approaches were used to synthesize both qualitative and quantitative data to examine the prevalence of the overlapping sequalae between endometriosis and psychiatric symptoms and disorders. As part of this, an evidence synthesis protocol was developed which included a systematic review protocol that was published on PROSPERO (CRD42020181495). The aim was to identify and evaluate mental health reported outcomes and prevalence of symptoms and psychiatric disorders associated with endometriosis.

findingsA total of 34 papers were included in the systematic review and 15 were included in the meta-analysis. Anxiety and depression symptoms were the most commonly reported mental health outcomes while a pooled analysis also revealed high prevalence of chronic pelvic pain and dyspareunia.

interpretationIt is evident that small-scale cross-sectional studies have been conducted in a variety of settings to determine mental health outcomes among endometriosis patients. Further research is required to comprehensively evaluate the mental health sequalae with endometriosis.

Indexed as

DyspareuniaEndometriosisCross-Sectional StudiesDysmenorrheaFemaleHumansMental HealthPelvic PainadenomyosisBAMEchronic pelvic paindysmenorrheadyspareuniaendometriosismental healthwomen’s healthwomen’s mental health

Identifiers

PMID34053382
PMCPMC8182632
OpenAlexW3164259130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.