ArticleJournal of assisted reproduction and genetics2021
The slippery slope antedating syngamy: pronuclear activity in preparation for the first cleavage.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Time-series clustering of the migration speed of nucleolus-precursor bodies in human zygotes and live birth following assisted reproductive technology.Journal of assisted reproduction and genetics · 2025Article
- Morphometric and morphokinetic differences in the sperm- and oocyte-originated pronuclei of male and female human zygotes: a time-lapse study.Journal of assisted reproduction and genetics · 2022Article
- The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization-derived human embryo ploidy status and live birth.Reproductive medicine and biologyArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleolus precursor bodies (NPB) are aggregations of intrapronuclear material observed in the pronuclei of fertilized human eggs. They derive from and evolve into nucleoli of the growing oocyte and the early embryo, respectively. Decades-old observations suggest that the patterns of their distribution represent a morphological marker of embryo developmental competence. Recent time-lapse microscopy (TLM) data now indicate that the vectorial characteristics of NPB movement can predict blastocyst formation, euploidy, and implantation. Since distributions of NPB and chromatin coincide, chromatin rearrangement in preparation for the first mitotic cleavage is emerging as a crucial process of early development.
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