Evidence map›Paper›PMID 34052976›Full record

ArticleJournal of thrombosis and thrombolysis2021

Atherothrombosis model by silencing of protein C in APOE*3-Leiden.CETP transgenic mice.

Yvonne K Jongejan, Jeroen C J Eikenboom, Marion J J Gijbels, Jimmy F P Berbée, Bart J M van Vlijmen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Silencing of the von Willebrand factor gene in proatherothromboticResearch and practice in thrombosis and haemostasis · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yvonne K JongejanDepartment of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-1118-7005
Jeroen C J EikenboomDepartment of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Marion J J GijbelsDepartment of Medical Biochemistry, Experimental Vascular Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Jimmy F P BerbéeEinthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Bart J M van VlijmenDepartment of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. b.j.m.van_vlijmen@lumc.nl.
Leiden University Medical Center · NLMaastricht University · NL

Funding

Trombosestichting Nederland 2018-1
6 · The paper itself

Abstract

Murine atherosclerosis models are key for investigation of atherosclerosis pathophysiology and drug development. However, they do not feature spontaneous atherothrombosis as a final stage of atherosclerosis. Transgenic mice expressing both the human mutant apolipoprotein E form APOE*3-Leiden and human cholesteryl ester transfer protein (CETP), i.e. APOE*3-Leiden.CETP mice, feature a moderate hyperlipoproteinemia and atherosclerosis phenotype. In contrast to apolipoprotein E deficient (Apoe-

Indexed as

AtherosclerosisThrombosisAnimalsApolipoproteins ECholesterol Ester Transfer ProteinsFemaleLipidsMiceMice, TransgenicPharmaceutical PreparationsProtein CApolipoproteins ECholesterol Ester Transfer ProteinsLipidsPharmaceutical PreparationsProtein CApolipoprotein E3AtherosclerosisMiceProtein CThrombosis

Identifiers

PMID34052976
PMCPMC8568858
OpenAlexW3164416058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.