Predictive value of anti-Müllerian hormone on pregnancy outcomes in in-vitro fertilization/intracytoplasmic single sperm injection patients at different ages.

Yujing Zhang, Liling Wang, Sijia Zhao, Cuilian Zhang, Qiaohua He, Aihua Liao

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Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yujing ZhangInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Liling WangInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Sijia ZhaoInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Cuilian ZhangDepartment of Reproductive Medicine Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan, P.R. China.

Qiaohua HeDepartment of Reproductive Medicine Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan, P.R. China. hqhuaaaa@126.com.

Aihua LiaoInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. aihua_liao@sina.com.ORCID http://orcid.org/0000-0001-8533-8315

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6 · The paper itself

Abstract

purposeTo investigate the predictive value of AMH level for pregnancy outcomes in different age groups of IVF/ICSI patients.

methodsThe study was a cohort study that included 11,484 patients that had their first IVF/ICSI procedure between 2016 and 2019. All patients who met the inclusion and exclusion criteria were divided into 6 groups according to 5-year age intervals, namely, Group 1: 20-24 years (n = 725); Group 2: 25-29 years (n = 4019); Group 3: 30-34 years (n = 3600); Group 4: 35-39 years (n = 1915); Group 5: 40-44 years (n = 1006); and Group 6: ≥ 45 years (n = 219).

resultsReceiver operating characteristic (ROC) curve analysis revealed that AMH level could only predict the outcome of live birth in Group 3 and Group 4 (p < 0.05). The area under the curve (AUC) of Group 3 was 0.536 (95% CI 0.510-0.561, p = 0.006), and that of Group 4 was 0.562 (95% CI 0.527-0.598, p = 0.001). The cutoff values of AMH for predicting live birth in Group 3 and Group 4 were 1.84 ng/ml and 1.86 ng/ml, respectively. Further logistic regression analysis showed that only the cutoff values of AMH and age could predict live birth in Groups 3 and 4.

conclusionsAMH level could predict live birth in IVF/ICSI patients at the age of 30-39. However, it could not be used to predict live birth in patients < 30 years or ≥ 40 years.

Indexed as

Anti-Mullerian HormoneSperm Injections, IntracytoplasmicAdultCohort StudiesFemaleFertilizationFertilization in VitroHumansLive BirthMaleMiddle AgedPregnancyPregnancy OutcomePregnancy RateRetrospective StudiesSpermatozoaAnti-Mullerian HormoneAnti-Müllerian hormoneIntracytoplasmic single sperm injectionIn vitro fertilizationLive birthReproductive aging

Identifiers

PMID34052875

DOI10.1016/j.rbmo.2010.11.005

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