ArticleNeuroImage2021
Brain network reorganization after targeted attack at a hub region.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks.Communications engineering · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Causal disconnectomics of motion perception networks: insights from transcranial magnetic stimulation-induced BOLD responses.The Journal of physiology · 2026Article
- Review
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Investigating the relationships of structural and functional neural networks of primary visual cortex with engineered AAVs and chemogenetic-fMRI techniques.Theranostics · 2025Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
- Perturbing cortical networks:Frontiers in neuroscience · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.bioRxiv : the preprint server for biology · 2023Article
- Network models to enhance the translational impact of cross-species studies.Nature reviews. Neuroscience · 2023Review
- Sex differences in resting-state functional networks in awake rats.Brain structure & function · 2023Article
- Sex differences in resting-state functional networks in awake rats.Research square · 2023Article
- Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network.Nature communications · 2023Article
- Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli.Science advances · 2023Article
- The use of chemogenetic actuator ligands in nonhuman primate DREADDs-fMRI.Current research in neurobiology · 2023Article
- Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism.Cerebral cortex communications · 2023Article
- Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept.Micromachines · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The architecture of brain networks has been extensively studied in multiple species. However, exactly how the brain network reconfigures when a local region, particularly a hub region, stops functioning remains elusive. By combining chemogenetics and resting-state functional magnetic resonance imaging (rsfMRI) in an awake rodent model, we investigated the causal impact of acutely inactivating a hub region (i.e. the dorsal anterior cingulate cortex) on brain network properties. We found that suppressing neural activity in a hub could have a ripple effect that went beyond the hub-related connections and propagated to other neural connections across multiple brain systems. In addition, hub dysfunction affected the topological architecture of the whole-brain network in terms of the network resilience and segregation. Selectively inhibiting excitatory neurons in the hub further changed network integration. None of these changes were observed in sham rats or when a non-hub region (i.e. the primary visual cortex) was perturbed. This study has established a system that allows for mechanistically dissecting the relationship between local regions and brain network properties. Our data provide direct evidence supporting the hypothesis that acute dysfunction of a brain hub can cause large-scale network changes. These results also provide a comprehensive framework documenting the differential impact of hub versus non-hub nodes on network dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.