ArticleNeuroImage2021
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [
Abstract readComparative Study
In one paragraph
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Molecular Aspects of Geriatric Pharmacotherapy.Cells · 2025Review
- Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study.Alzheimer's research & therapy · 2025Article
- An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [European journal of nuclear medicine and molecular imaging · 2024Article
- Markerless head motion tracking and event-by-event correction in brain PET.Physics in medicine and biology · 2023Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Persisting Verbal Memory Encoding and Recall Deficiency after mGluR5 Autoantibody-Mediated Encephalitis.Brain sciences · 2023Article
- Article
- Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.Neurobiology of disease · 2022Article
- Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study.Brain sciences · 2022Article
- Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization.Frontiers in psychiatry · 2022Review
- Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?Frontiers in pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Adam P MeccaAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address: adam.mecca@yale.edu.
Kelly RogersAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Zachary JacobsAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Julia W McDonaldAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hannah R MichalakAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nicole DellaGioiaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Wenzhen ZhaoAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Ansel T HillmerDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Keunpoong LimDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Jim RopchanDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
David MatuskeyDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Irina EsterlisDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Christopher H van DyckAlzheimer's Disease Research Unit, Yale University School of Medicine, One Church Street, 8th Floor, New Haven, CT, 06514, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2MPrion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6MYale Alzheimer Disease Research CenterP50AG047270 · NIA · YALE UNIVERSITY · PI MAROTTOLI, RICHARD · 2015 to 2019
$8.3MPET-fMRI Study of Glutamate and Frontal Function in Bi- and Uni-polar DepressionR01MH104459 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2015 to 2019
$3.6MInvestigation of molecular changes in mGluR5 and SV2A to study synaptic alterations in Alzheimer's disease using PET.K23AG057794 · NIA · YALE UNIVERSITY · PI MECCA, ADAM PETER · 2018 to 2022
$977kMultimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894kNCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIA NIH HHS K23 AG057794NIA NIH HHS P30 AG066508NIA NIH HHS P50 AG047270NIA NIH HHS R01 AG034924NIMH NIH HHS R01 MH104459
Abstract
objectiveMetabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.
methodsCognitively normal participants (n = 45), aged 18 to 84 years, underwent [
resultsIn the primary analysis, older age was associated with lower [
conclusionReductions in mGluR5 availability with age appear to be largely mediated by tissue loss. Quantification of [
Indexed as
Brain ChemistryNeuroimagingPositron-Emission TomographyAdolescentAdultAgedAged, 80 and overAgingFemaleFluorine RadioisotopesFluorodeoxyglucose F18Gray MatterHippocampusHumansMagnetic Resonance ImagingMaleFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18GRM5 protein, humanRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5[(18)F]FPEB, PETAgingGlutamate receptormGluR5
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.