ArticleBrain, behavior, and immunity2021
Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation.
Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- In vivo quantitative imaging of hippocampal inflammation in autoimmune neuroinflammatory conditions: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Network-based disease fingerprinting with neuroinflammation PET imaging.Journal of neuroinflammation · 2026Article
- 18F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt-Jakob disease: a case report.BMJ neurology open · 2026Article
- Network-based disease fingerprinting with neuroinflammation PET imaging.Research square · 2025Article
- Extra-axial inflammatory signal and its relationship to peripheral and central immunity in depression.Brain : a journal of neurology · 2025Article
- 18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate.Brain, behavior, and immunity · 2025Article
- Article
- A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.Frontiers in neuroscience · 2024Article
- [European journal of nuclear medicine and molecular imaging · 2023Article
- Imidazoline-I2 PET Tracers in Neuroimaging.International journal of molecular sciences · 2023Review
- Brain and Systemic Inflammation in De Novo Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease.Journal of neuroinflammation · 2023Article
- Dynamic microglial activation is associated with LPS-induced depressive-like behavior in mice: An [18F] DPA-714 PET imaging study.Bosnian journal of basic medical sciences · 2022Article
- Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization.Pharmacology & therapeutics · 2022Review
- Characterization of neuroinflammatory positron emission tomography biomarkers in chronic traumatic encephalopathy.Brain communications · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
The increased expression of 18 kDa Translocator protein (TSPO) is one of the few available biomarkers of neuroinflammation that can be assessed in humans in vivo by positron emission tomography (PET). TSPO PET imaging of the central nervous system (CNS) has been widely undertaken, but to date no clear consensus has been reached about its utility in brain disorders. One reason for this could be because the interpretation of TSPO PET signal remains challenging, given the cellular heterogeneity and ubiquity of TSPO in the brain. The aim of the current study was to ascertain if TSPO PET imaging can be used to detect neuroinflammation induced by a peripheral treatment with a low dose of the endotoxin, lipopolysaccharide (LPS), in a rat model (ip LPS), and investigate the origin of TSPO signal changes in terms of their cellular sources and regional distribution. An initial pilot study utilising both [
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