ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2022
Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Trial
- Efficacy of Yishen Jiangzhuo granules in the treatment of chronic kidney disease stages 3-4: a retrospective cohort study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Ethnic Disparities in CKD Progression: A Comparative Study of CRIC and KNOW-CKD Cohorts.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Heterogeneity of Estimated GFR Slopes According to Etiology, Estimated GFR and Urinary Albumin-to-Creatinine Ratio in a Large Cohort of Patients With CKD.Kidney international reports · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Associations of Proteinuria Trajectories with Kidney Failure and Death in Individuals with CKD.Kidney360 · 2025Article
- Cardiovascular and Thromboembolic Events in Children and Adults With Glomerular Disease: Findings From the Cure GlomeruloNephropathy (CureGN) Network.Kidney medicine · 2025Article
- Article
- Cardiovascular and Kidney Outcomes of Non-Diabetic CKD by Albuminuria Severity: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Cardiac Effects of Renin-Angiotensin System Inhibitors in Nonproteinuric CKD.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Association between Urine Specific Gravity as a Measure of Hydration Status and Risk of Type 2 Diabetes: The Kailuan Prospective Cohort Study.Nutrients · 2024Article
- Association of the longitudinal trajectory of urinary albumin/creatinine ratio in diabetic patients with adverse cardiac event risk: a retrospective cohort study.Frontiers in endocrinology · 2024Article
- Machine learning model for cardiovascular disease prediction in patients with chronic kidney disease.Frontiers in endocrinology · 2024Article
- Obesity Weight Loss Phenotypes in CKD: Findings from the Chronic Renal Insufficiency Cohort Study.Kidney international reports · 2023Article
- Characteristics, Prognosis, and Prediction Model of Heart Failure Patients in Intensive Care Units Based on Preserved, Mildly Reduced, and Reduced Ejection Fraction.Reviews in cardiovascular medicine · 2023Article
- Self-reported Physical Activity and Cardiovascular Events in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Progression of Chronic Kidney Disease Risk Categories and Risk of Cardiovascular Disease and Total Mortality: Coronary Artery Risk Development in Young Adults Cohort.Journal of the American Heart Association · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
Abstract
RATIONALE &
objectiveEvaluating repeated measures of estimated glomerular filtration rate (eGFR) and urinary protein-creatinine ratio (UPCR) over time may enhance our ability to understand the association between changes in kidney parameters and cardiovascular disease risk. STUDY
designProspective cohort study. SETTING &
participantsAnnual visit data from 2,438 participants in the Chronic Renal Insufficiency Cohort (CRIC). EXPOSURES: Average and slope of eGFR and UPCR in time-updated, 1-year exposure windows. OUTCOMES: Incident heart failure, atherosclerotic cardiovascular disease events, death, and a composite of incident heart failure, atherosclerotic cardiovascular disease events, and death. ANALYTICAL APPROACH: A landmark analysis, a dynamic approach to survival modeling that leverages longitudinal, iterative profiles of laboratory and clinical information to assess the time-updated 3-year risk of adverse cardiovascular outcomes.
resultsAdjusting for baseline and time-updated covariates, every standard deviation lower mean eGFR (19mL/min/1.73m LIMITATIONS: Limited generalizability of annual eGFR and UPCR assessments; several biomarkers for cardiovascular disease risk were not available annually.
conclusionsUsing the landmark approach to account for time-updated patterns of kidney function, average and slope of eGFR and proteinuria were independently associated with 3-year cardiovascular risk. Short-term changes in kidney function provide information about cardiovascular risk incremental to level of kidney function, representing possible opportunities for more effective management of patients with chronic kidney disease.
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