ReviewBiological psychiatry2021
The Neurocircuitry of Posttraumatic Stress Disorder and Major Depression: Insights Into Overlapping and Distinct Circuit Dysfunction-A Tribute to Ron Duman.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- A Systematic Review of Neurocognitive Effects of Subanesthetic Doses of Intravenous Ketamine in Major Depressive Disorder, Post-Traumatic Stress Disorder, and Healthy Population.Clinical drug investigation · 2022Pooled it
- The Role of Kappa-Opioid Receptor/Dynorphin System in Modulating Neural-Circuits of Depression and Anxiety-A Review.Journal of cellular and molecular medicine · 2026Review
- Transcriptome changes of disinhibited somatostatin neurons in the medial prefrontal cortex mediating male-specific stress resilience.Research square · 2026Article
- Perspective: Depression in Persons with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Antidepressant-like effects of extinction learning as an animal model of behavioral therapy.Molecular psychiatry · 2026Article
- Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors.Molecular psychiatry · 2026Article
- Gender differences in symptom profiles of individuals being treated for mood disorders.Journal of mood and anxiety disorders · 2025Article
- Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory.Fundamental research · 2025Review
- Within-person associations of daily activity to sleep actigraphy following trauma: Explicating a novel index of risk for major depressive disorder and posttraumatic stress disorder.Journal of psychopathology and clinical science · 2025Article
- Telomere Dynamics in Post-Traumatic Stress Disorder: A Critical Synthesis.Biomedicines · 2025Review
- Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women.Psychological medicine · 2025Article
- The Impact of Seasonality on Mental Health Disorders: A Narrative Review and Extension of the Immunoseasonal Theory.Journal of clinical medicine · 2025Review
- The role of brain creatine in behavioral health conditions.Frontiers in psychiatry · 2025Review
- Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.Brain : a journal of neurology · 2024Article
- Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders-An Overview of Experimental Evidence.Nutrients · 2024Review
- Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women.medRxiv : the preprint server for health sciences · 2024Article
- Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens.Psychological medicine · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The neurocircuitry that contributes to the pathophysiology of posttraumatic stress disorder and major depressive disorder, psychiatric conditions that exhibit a high degree of comorbidity, likely involves both overlapping and unique structural and functional changes within multiple limbic brain regions. In this review, we discuss neurobiological alterations that are associated with posttraumatic stress disorder and major depressive disorder and highlight both similarities and differences that may exist between these disorders to argue for the existence of a shared neurobiology. We highlight the key contributions based on preclinical studies, emerging from the late Professor Ronald Duman's research, that have shaped our understanding of the neurocircuitry that contributes to both the etiopathology and treatment of major depressive disorder and posttraumatic stress disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.