Evidence map›Paper›PMID 34051983›Full record

GuidelineGastroenterology2021

AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease.

Joseph D Feuerstein, Edith Y Ho, Eugenia Shmidt, Harminder Singh, Yngve Falck-Ytter, Shanaz Sultan, Jonathan P Terdiman, American Gastroenterological Association Institute Clinical Guidelines Committee

Registry-linked trialAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07616687 (Optimal Care With Guselkumab In Crohn's Disease), which is not on this map. Cited by 198 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 25 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07616687 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Optimal Care With Guselkumab In Crohn's Disease

TypeinterventionalSponsorGroupe d'Etude Therapeutique des Affections Inflammatoires DigestivesRan2026 to 2029Enrolled210ConditionsCrohn Disease (CD), IntensificationArmsGuselkumab
3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 25 syntheses or guidelines pooled it.

  1. Pooled it
  2. Perianal fistulizing Crohn's disease: Clinical practice update from Colitis and Crohn's Foundation (India).Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Guideline
  3. Pooled it
  4. Efficacy of Advanced Therapies in Achieving Remission by Disease Location in Crohn's Disease: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Guideline
  17. Infliximab for medical induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2023
    Pooled it
  18. Vitamin D for the treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2023
    Pooled it
  19. Pooled it
  20. Remote care through telehealth for people with inflammatory bowel disease.The Cochrane database of systematic reviews · 2023
    Pooled it

138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph D FeuersteinDivision of Gastroenterology and Center for Inflammatory Bowel Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Edith Y HoDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, California.
Eugenia ShmidtDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota.
Harminder SinghSection of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada.
Yngve Falck-YtterDivision of Gastroenterology, Case Western Reserve University, and Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio.
Shanaz SultanDivision of Gastroenterology, University of Minnesota, Minneapolis, Minnesota.
Jonathan P TerdimanDivision of Gastroenterology, University of California, San Francisco, San Francisco, California.
American Gastroenterological Association Institute Clinical Guidelines Committee

Funding

Comparative Risks and Benefits of Pharmacological Therapies for Older Patients with Inflammatory Bowel DiseasesK23DK117058 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINGH, SIDDHARTH · 2018 to 2022
$971k
NIDDK NIH HHS K23 DK117058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Disease ManagementCrohn DiseaseGastroenterologyHumansIntestinal MucosaMinimal Clinically Important DifferencePatient SelectionRectal FistulaSocieties, Medical

Identifiers

PMID34051983
PMCPMC8988893

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.