Evidence map›Paper›PMID 34051936›Full record

Trial reportThe lancet. Diabetes & endocrinology2021

Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study.

Alan M Jacobson, Christopher M Ryan, Barbara H Braffett, Rose A Gubitosi-Klug, Gayle M Lorenzi, José A Luchsinger, Victoria R Trapani, Ionut Bebu, Naomi Chaytor, Susan M Hitt and 3 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Alan M JacobsonNYU Long Island School of Medicine, NYU Langone Hospital-Long Island, Mineola, NY, USA. Electronic address: alan.jacobson@nyulangone.org.
Christopher M RyanUniversity of Pittsburgh, Pittsburgh, PA, USA.
Barbara H BraffettGeorge Washington University, Biostatistics Center, Rockville, MD, USA.
Rose A Gubitosi-KlugCase Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Gayle M LorenziUniversity of California San Diego, La Jolla, CA, USA.
José A LuchsingerColumbia University Irving Medical Center, New York, NY, USA.
Victoria R TrapaniGeorge Washington University, Biostatistics Center, Rockville, MD, USA.
Ionut BebuGeorge Washington University, Biostatistics Center, Rockville, MD, USA.
Naomi ChaytorElson S Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Susan M HittColumbia School of Medicine, University of Missouri, Columbia, MO, USA.
Kaleigh FarrellCase Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
John M LachinGeorge Washington University, Biostatistics Center, Rockville, MD, USA.
DCCT/EDIC Research Group
George Washington University · USCase Western Reserve University · USColumbia University Irving Medical Center · USRainbow Babies & Children's Hospital · USUniversity of California, San Diego · USUniversity of Missouri · USUniversity of Pittsburgh · USWashington State University Spokane · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Effects of Biomedical Risk Factors on Neuro-cognition Using MRI: Long term follow-up of the Diabetes Control & Complications Trial/Epidemiology of Diabetes Interventions and Complications Study CohortDP3DK114812 · NIDDK · NYU WINTHROP HOSPITAL · PI JACOBSON, ALAN M · 2017 to 2019
$4.7M
Midcareer Award for Research in Dementia Risk Factors and PreventionK24AG045334 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jose Alejandro Luchsinger · 2016 to 2026
$1.5M
NIA NIH HHS K24 AG045334NIDDK NIH HHS DP3 DK114812NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

backgroundWith improved treatment, individuals with type 1 diabetes are living longer but there is limited information on the effects of type 1 diabetes on cognitive ability as they become older adults. We followed up individuals with type 1 diabetes to identify independent risk factors for cognitive decline as people age.

methods1051 participants with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study. Participants completed cognitive assessments at baseline (median age 27 years) and 2, 5, 18, and 32 years later (median age 59). HbA

findingsOver 32 years of follow-up, we found substantive declines in memory and psychomotor and mental efficiency. Between 18 and 32 years of follow-up, the decline in psychomotor and mental efficiency was five times larger than the change from baseline to year 18. Independent of the other risk factors and comorbidities, exposure to higher HbA

interpretationCognitive function declines with ageing in type 1 diabetes. The association of glycaemia and blood pressure levels with cognitive decline suggests that better management might preserve cognitive function.

fundingUnited States National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease.

Indexed as

AdolescentAdultAgedCognitionCognitive DysfunctionDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHumansMaleMiddle AgedTime FactorsYoung Adult

Identifiers

PMID34051936
PMCPMC8583716
OpenAlexW3164205577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.