SynthesisThe international journal of behavioral nutrition and physical activity2021
Muscle-strengthening activities and cancer incidence and mortality: a systematic review and meta-analysis of observational studies.
Synthesis in The international journal of behavioral nutrition and physical activity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06987708 (Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance), which is not on this map. Cited by 32 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study
Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta-Analyses.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- The associations of muscle-strengthening exercise with recurrence and mortality among breast cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2024Pooled it
- Effects of resistance training on sleep quality and disorders among individuals diagnosed with cancer: A systematic review and meta-analysis of randomized controlled trials.Cancer medicine · 2024Pooled it
- Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies.British journal of sports medicine · 2022Pooled it
- Exercise and Oxidative Stress Biomarkers among Adult with Cancer: A Systematic Review.Oxidative medicine and cellular longevity · 2022Pooled it
- International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines.The journal of nutrition, health & aging · 2021Guideline
- Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026Review
- Sex-specific changes in appetite and energy intake in response to chronic resistance training in rats.Physiological reports · 2026Article
- Long-term resistance training with all-cause and cause-specific mortality: assessing dose-response and joint associations with aerobic physical activity.British journal of sports medicine · 2026Article
- Physical activity for public health in the 21st century.Nature medicine · 2026Review
- Kinetic Human Movement Ontology: a semantic terminology model to symbolically represent physiological movement.Scientific data · 2026Article
- Meeting the WHO guideline on muscle-strengthening activities does not have to be time-consuming: a discussion of time-saving strategies.Frontiers in public health · 2026Article
- Adherence to physical activity guidelines and all-cause and cardiovascular disease mortality in individuals with and without type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Opportunities for Artificial Intelligence in Oncology: From the Lens of Clinicians and Patients.JCO oncology practice · 2025Review
- Exploration of Fully-Automated Body Composition Analysis Using Routine CT-Staging of Lung Cancer Patients for Survival Prognosis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Moderating Effect of Muscular Strength in the Association Between Cancer and Depressive Symptomatology.Healthcare (Basel, Switzerland) · 2025Article
- Article
- The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities.British journal of cancer · 2024Review
- Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study.BMJ public health · 2024Article
- Weight training and risk of all-cause, cardiovascular disease and cancer mortality among older adults.International journal of epidemiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity has been associated with reduced risk of seven types of cancer. It remains unclear, however, whether muscle-strengthening activities also reduce cancer incidence and mortality.
methodsPubMed, Embase, Web of Science and Scopus were searched from inception to March 2020. Summary hazard ratio (HR) and 95% confidence intervals (CI) were estimated using random-effects models.
resultsTwelve studies (11 cohorts; 1 case-control), 6 to 25 years of follow-up, including 1,297,620 participants, 32,196 cases and 31,939 deaths, met inclusion criteria. Muscle-strengthening activities were associated with a 26% lower incidence of kidney cancer (HR for high vs low levels of muscle-strengthening activities: 0.74; 95% CI 0.56 to 0.98; I
conclusionsMuscle-strengthening activities were associated with reduced incidence of kidney cancer and total cancer mortality. Combined muscle-strengthening and aerobic activities may provide a greater reduction in total cancer mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.