Evidence map›Paper›PMID 34051302›Full record

ReviewCritical reviews in oncology/hematology2021

Hematopoietic stem cell stretches and moves in its bone marrow niche.

Walison N Silva, Alinne C Costa, Caroline C Picoli, Beatriz G S Rocha, Gabryella S P Santos, Pedro A C Costa, Parviz Azimnasab-Sorkhabi, Maryam Soltani-Asl, Rodrigo A da Silva, Jaime Henrique Amorim and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical reviews in oncology/hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Circulating Nestin-GFPStem cell reviews and reports · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Walison N SilvaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Alinne C CostaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Caroline C PicoliDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Beatriz G S RochaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Gabryella S P SantosDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Pedro A C CostaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Parviz Azimnasab-SorkhabiDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Maryam Soltani-AslDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Rodrigo A da SilvaDepartment of Dentistry, University of Taubaté, Taubaté, São Paulo, Brazil.
Jaime Henrique AmorimCenter of Biological Sciences and Health, Federal University of West Bahia, Barreiras, BA, Brazil.
Rodrigo R ResendeDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA.

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072
6 · The paper itself

Abstract

Hematopoietic stem cells are the most illustrious inhabitants of the bone marrow. Direct visualization of endogenous hematopoietic stem cells in this niche is essential to study their functions. Until recently this was not possible in live animals. Recent studies, using state-of-the-art technologies, including sophisticated in vivo inducible genetic approaches in combination with two-photon laser scanning microscopy, allow the follow-up of endogenous hematopoietic stem cells' behavior in their habitat. Strikingly, the new findings reveal that quiescent hematopoietic stem cells are more mobile than previously thought, and link their retained steady state within the niche to a mobile behavior. The arising knowledge from this research will be critical for the therapy of several hematological diseases. Here, we review recent progress in our understanding of hematopoietic stem cell biology in their niches.

Indexed as

Bone MarrowStem Cell NicheAnimalsBone Marrow CellsCell DivisionHematopoietic Stem CellsHumansHematopoietic stem cellsMicroenvironmentNicheTwo-photon laser scanning microscopy

Identifiers

PMID34051302
PMCPMC8277710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.