ArticleMicrobiology and immunology2021
cydA, spdC, and mroQ are novel genes involved in the plasma coagulation of Staphylococcus aureus.
Article in Microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Ultrahigh-throughput screening of heterogeneous vancomycin-intermediate Staphylococcus aureus based on fluorescence-activated droplet sorting.BMC medicine · 2025Article
- Simple and accurate genomic classification model for distinguishing between human and pig Staphylococcus aureus.Communications biology · 2024Article
- Reconstitution of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- cydA, spdC, and mroQ are novel genes involved in the plasma coagulation of Staphylococcus aureus.Microbiology and immunology · 2021Article
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6 authors at 2 institutions in 1 country.
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Abstract
Coagulation is a critical pathogenic process in Staphylococcus aureus. Although the agglutination of S. aureus has been studied for a long time, the genes involved in this process are not completely clear. We performed tube agglutination and dynamic turbidimetry tests to identify novel genes involved in reduced plasma coagulation. A total of 15 genes were identified, including coa, clfA, vwbp, saeS, agrA, trpC, spdC, mroQ, cydA, qoxC, sucC, pyrP, menH, threonine aldolase, and truncated transposase for IS1272. The functions of these genes include bicomponent regulation, membrane transport, energy metabolism and biosynthesis, respectively. cydA, spdC, and mroQ genes were further studied by gene knockout and complementation. Results of gene knockout and complementation and real-time-qPCR proved that cydA, spdC, and mroQ genes are necessary for plasma coagulation. Furthermore, the survival ability of 7 day mice decreased significantly when cydA, spdC, and mroQ genes had been knocked out.
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