ArticleJournal of the American Geriatrics Society2021
Prefrailty, impairment in physical function, and risk of incident heart failure among older adults.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A Systematic Review of Frailty Interventions in Community-Based Low and Middle-Income Settings.International journal of public health · 2025Pooled it
- Association of Baseline and Longitudinal Changes in Frailty Burden and Risk of Heart Failure in Type 2 Diabetes-Findings from the Look AHEAD Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Trial
- Sarcopenia and Its Associated Metabolic Profile Predict Incident Heart Failure: A Prospective Cohort Study of 267 335 Adults in the UK Biobank.Journal of the American Heart Association · 2026Article
- Association Between Locomotive Syndrome and N-Terminal Pro B-Type Natriuretic Peptide Concentration in a Health Screening Cohort: A Retrospective Cross-Sectional Study.Circulation reports · 2026Article
- Frailty as an independent predictor of one-year outcomes in patients with HFpEF after acute myocardial infarction: insights from a multicenter retrospective cohort in China.Journal of geriatric cardiology : JGC · 2025Article
- Article
- Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.Nature communications · 2024Article
- Bidirectional Association Between Frailty and Cardiac Structure and Function: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2023Article
- Association between handgrip strength and heart failure in adults aged 45 years and older from NHANES 2011-2014.Scientific reports · 2023Article
- Developing a Parsimonious Frailty Index for Older, Multimorbid Adults With Heart Failure Using Machine Learning.The American journal of cardiology · 2023Article
- Geriatric Cardiology: Coming of Age.JACC. Advances · 2022Article
- Moving the Field Forward: Untangling the Impact of Frailty on Patients With Advanced Heart Failure and on Prognosticating Outcomes.Journal of cardiac failure · 2022Article
- Frailty, Guideline-Directed Medical Therapy, and Outcomes in HFrEF: From the GUIDE-IT Trial.JACC. Heart failure · 2022Article
- A Simple Risk Score Based on Routine Clinical Parameters Can Predict Frailty in Hospitalized Heart Failure Patients.Journal of clinical medicine · 2021Article
- Beyond Physical Impairment: The Role of Social Frailty in Heart Failure.Journal of the American Heart Association · 2021Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveEvaluate the association between prefrailty and the risk of heart failure (HF) among older adults. DESIGN, SETTING, AND
participantsThis prospective, community-based cohort study included participants from the Atherosclerotic Risk in Communities study who underwent detailed frailty assessment using Fried Criteria and physical function assessment using the Short Performance Physical Battery (SPPB) score. Individuals with prevalent HF and frailty were excluded. MAIN OUTCOMES AND MEASURES: Adjusted association between prefrailty (vs robust), physical function measures (SPPB score, grip strength, and gait speed), and incident HF (overall and HF subtypes, HF with reduced [HFrEF, EF < 50%] and preserved ejection fraction [HFpEF]) were assessed using Cox proportional hazards models.
resultsAmong 5210 participants (mean age 75 years, 58% women), 2565 (49.2%) were identified as prefrail. In cross-sectional analysis, prefrail individuals had a higher burden of chronic myocardial injury (troponin, Std β = 0.08 [0.05-0.10]) and neurohormonal stress (NT-ProBNP, Std β = 0.03 [0.02-0.05]) after adjustment for potential confounders. Over a median follow-up of 4.6 years, there were 232 (4.5%) HF events (HFrEF: 102; HFpEF: 97). Prefrailty was associated with an increased risk of HF after adjusting for potential clinical confounders and cardiac biomarkers (aHR [95% CI] = 1.65 [1.24-2.20]). Among HF subtypes, prefrailty was associated with an increased risk of HFpEF but not HFrEF (aHR [95% CI] = 1.73 [1.11-2.70] and 1.38 [0.90-2.10], respectively). A lower SPPB score was also associated with an increased risk of overall HF and HFpEF, but not HFrEF. Among individual components, increased gait speed were associated with a lower risk of HFpEF, but not HFrEF. CONCLUSIONS AND RELEVANCE: Subtle abnormalities in physiological reserve (prefrailty) and impairment in physical function (SPPB) were both significantly associated with a higher risk of incident HF, particularly HFpEF. These findings highlight the potential role of routine assessment of geriatric syndromes for early identification of HF risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.