Evidence map›Paper›PMID 34050853›Full record

ReviewCurrent cardiology reports2021

Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair.

Xiao-Dong Zhang, Phung N Thai, Deborah K Lieu, Nipavan Chiamvimonvat

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current cardiology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xiao-Dong ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 95616, USA.
Phung N ThaiDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 95616, USA.
Deborah K LieuDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 95616, USA.
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 95616, USA. nchiamvimonvat@ucdavis.edu.ORCID 0000-0001-9499-8817
VA Northern California Health Care System · USUniversity of California, Davis · USUniversity of California System · US

Funding

Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
Functional Regulation of Cardiac Chloride HomeostasisR56HL138392 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZHANG, XIAO-DONG · 2018 to 2018
$393k
Novel Mechanisms of Cardiac pH Regulation During Ischemia/ReperfusionF32HL149288 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI THAI, PHUNG NHAT · 2019 to 2020
$91k
BLRD VA I01 BX000576CSRD VA I01 CX001490NHLBI NIH HHS F32 HL149288NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R56 HL138392NHLBI NIH HHS T32 HL086350
6 · The paper itself

Abstract

purpose of reviewCardiac cell-based therapy represents a promising approach for cardiac repair. However, one of the main challenges is cardiac arrhythmias associated with stem cell transplantation. The current review summarizes the recent progress in model systems for addressing mechanisms of arrhythmogenesis in cardiac repair. RECENT

findingsAnimal models have been extensively developed for mechanistic studies of cardiac arrhythmogenesis. Advances in human induced pluripotent stem cells (hiPSCs), patient-specific disease models, tissue engineering, and gene editing have greatly enhanced our ability to probe the mechanistic bases of cardiac arrhythmias. Additionally, recent development in multiscale computational studies and machine learning provides yet another powerful tool to quantitatively decipher the mechanisms of cardiac arrhythmias. Advancing efforts towards the integrations of experimental and computational studies are critical to gain insights into novel mitigation strategies for cardiac arrhythmias in cell-based therapy.

Indexed as

Induced Pluripotent Stem CellsAnimalsArrhythmias, CardiacCell- and Tissue-Based TherapyHumansMyocytes, CardiacStem Cell TransplantationAnimal models of cardiac arrhythmiasCardiac arrhythmiasCardiac cell-based therapyCardiac hypertrophyGenome editingHeart failureHuman-induced pluripotent stem cellsPatient-specific disease models

Identifiers

PMID34050853
PMCPMC8164614
OpenAlexW3165319406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.