Evidence map›Paper›PMID 34050832›Full record

ArticleBulletin of experimental biology and medicine2021

On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy.

S A Kryzhanovskii, L M Kozhevnikova, M B Vititnova, A O Efimova, V N Stolyaruk, I B Tsorin

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

S A KryzhanovskiiV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. sak-538@yandex.ru.
L M KozhevnikovaV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
M B VititnovaV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
A O EfimovaV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
V N StolyarukV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
I B TsorinV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Institute of Pharmacology Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.

Indexed as

Cardiomyopathy, AlcoholicAnimalsHeart VentriclesMyocardiumRatsRNA, MessengerRyanodine Receptor Calcium Release ChannelRNA, MessengerRyanodine Receptor Calcium Release Channelalcoholic cardiomyopathycardioprotectionechocardiographyexpression of mRNA of the CaM, Erac1, Erac2, RyR2, and IP3R2 genesfabomotizole

Identifiers

PMID34050832
OpenAlexW3164917042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.