Evidence map›Paper›PMID 34050517›Full record

ArticleEnvironmental science and pollution research international2021

Translation, ribosome biogenesis, and oxidative damage caused by chlorpyrifos exposure to common carp (Cyprinus carpio L.) liver: application of combined RNA-seq with sRNA-seq in risk evaluation of environmental toxicant chlorpyrifos.

Jing Fu, Minghui Wang, Maria T Chaudhry, Hongfei Xue, Lichun Zhang, Yanhua Huang, Chunpeng Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing FuInnovative Institute of Animal Healthy Breeding, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Minghui WangBioinformatics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.
Maria T ChaudhryFaculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Hongfei XueCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China.
Lichun ZhangInstitute of Animal Biotechnology, Jilin Academy of Agricultural Sciences (JAAS), Jilin, 136100, China. zhang_lich@163.com.
Yanhua HuangInnovative Institute of Animal Healthy Breeding, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China. huangyh111@126.com.
Chunpeng LiuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, No. 501 Zhongkai Road, Haizhu District, Guangzhou, China. liuchunpeng@163.com.

Funding

Characteristic innovation projects of ordinary colleges and universities in Guangdong Province 2018KTSCX102Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams and Department of Agriculture and Rural Affairs of Guangdong Province No. 2020KJ119
6 · The paper itself

Abstract

Pesticide chlorpyrifos (CPF) is a widespread environmental pollutant gaining attention as it is highly injurious to aquatic life. Although the toxicity of CPF is well characterized, but the mechanism of toxic response especially, the hepatotoxicity remained unclear. In this study, we performed integrated analysis, including micro-RNA (miRNA) and small RNA (sRNA) to analyze CPF exposure responding genes and enrichment pathways. A total of 23,742 expressed genes were detected and out of these expression levels of 1746 were changed significantly. Majority of them participated in protein biosynthesis, nucleotide binding, and oxidation-reduction activities. In extensive analysis of micro-RNA (miRNA) expression profiles by comparing CPF treated carp with control, we identified 214 novel miRNAs with CPM > 5 in at least one sample. The miRNAs have the same change in direction compared with overlapped mRNA pairs in upregulated genes, suggesting potential positive correlation. As a whole, we detected many differently expressed genes (DEGs) and miRNAs, which may be used as the biomarkers for the detection of CPF pollution in water and aquatic product safety. However, their functions are required to be deeply analyzed, especially more samples or time pointed data are needed to illustrate their concrete mechanism.

Indexed as

AtrazineCarpsChlorpyrifosInsecticidesWater Pollutants, ChemicalAnimalsLiverOxidative StressRibosomesRNA-SeqAtrazineChlorpyrifosInsecticidesWater Pollutants, ChemicalCarp liverChlorpyrifosEnvironmental pollutantmiRNA and sRNARisk evaluation

Identifiers

PMID34050517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.