Evidence map›Paper›PMID 34050505›Full record

ArticlePurinergic signalling2021

BAC transgenic mice to study the expression of P2X2 and P2Y

Marcus Grohmann, Michaela Schumacher, Janka Günther, Stefan M Singheiser, Tanja Nußbaum, Florian Wildner, Zoltan Gerevich, Ronald Jabs, Daniela Hirnet, Christian Lohr and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Marcus GrohmannRudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-0228-7063
Michaela SchumacherInstitute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Janka GüntherInstitute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Stefan M SingheiserInstitute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Tanja NußbaumInstitute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Florian WildnerInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Zoltan GerevichInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ronald JabsInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Daniela HirnetDivision of Neurophysiology, University of Hamburg, Hamburg, Germany.
Christian LohrDivision of Neurophysiology, University of Hamburg, Hamburg, Germany.
Peter IllesRudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany.
Günther SchmalzingInstitute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Heike Franke *Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany.
Ralf Hausmann *Institute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany. rhausmann@ukaachen.de.ORCID 0000-0002-0130-110X
RWTH Aachen University · DECharité - Universitätsmedizin Berlin · DELeipzig University · DEUniversität Hamburg · DETechnologie- und Förderzentrum im Kompetenzzentrum für Nachwachsende Rohstoffe · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular purines are important signaling molecules involved in numerous physiological and pathological processes via the activation of P2 receptors. Information about the spatial and temporal P2 receptor (P2R) expression and its regulation remains crucial for the understanding of the role of P2Rs in health and disease. To identify cells carrying P2X2Rs in situ, we have generated BAC transgenic mice that express the P2X2R subunits as fluorescent fusion protein (P2X2-TagRFP). In addition, we generated a BAC P2Y

Indexed as

AnimalsCells, CulturedChromosomes, Artificial, BacterialFemaleGanglia, SpinalGene ExpressionHEK293 CellsHumansMiceMice, Inbred C57BLMice, TransgenicReceptors, Purinergic P2X2Receptors, Purinergic P2Y1Xenopus laevisReceptors, Purinergic P2X2Receptors, Purinergic P2Y1BAC transgenic miceBrainP2X2 receptorP2Y1 receptorTagRFP

Identifiers

PMID34050505
PMCPMC8410928
OpenAlexW3165213007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.