Evidence map›Paper›PMID 34050449›Full record

ArticleJournal of assisted reproduction and genetics2021

Involvement of single nucleotide polymorphisms in ovarian poor response.

Sayyed Mohammad Hossein Ghaderian, Reza Akbarzadeh, Saghar Salehpour

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Sayyed Mohammad Hossein Ghaderian *Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza Akbarzadeh *Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Saghar SalehpourPreventative Gynecology Research Center (PGRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran. saghar.salehpour2014@gmail.com.ORCID http://orcid.org/0000-0003-3203-8444
Shahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUnpredictability in acquiring an adequate number of high-quality oocytes following ovarian stimulation is one of the major complications in controlled ovarian hyperstimulation (COH). Genetic predispositions of variations could alter the immunological profiles and consequently be implicated in the variability of ovarian response to the stimulation.

designUncovering the influence of variations in AMHR2, LHCGR, MTHFR, PGR, and SERPINE1 genes with ovarian response to gonadotrophin stimulation in COH of infertile women.

methodsBlood samples of the women with a good ovarian response (GOR) or with a poor ovarian response (POR) were collected. Genomic DNA was extracted, and gene variations were genotyped by TaqMan SNP Genotyping Assays using primer-probe sets or real-time PCR Kit.

resultsExcept for PGR (rs10895068), allele distributions demonstrate that the majority of POR patients carried minor alleles of AMHR2 (rs2002555, G-allele), LHCGR (rs2293275, G-allele), MTHFR (rs1801131, C-allele, and rs1801133, T-allele), and SERPINE1 (rs1799889, 4G allele) genes compared to the GOR. Similarly, genotypes with a minor allele in AMHR2, LHCGR, MTHFR, and SERPINE1 genes had a higher prevalence among POR patients with the polymorphic genotypes. However, further genotype stratification indicated that the minor alleles of these genes are not associated with poor response. Multivariate logistic analysis of clinical-demographic factors and polymorphic genotypes demonstrated a correlation between FSH levels and polymorphic genotypes of SERPINE1 in poor response status.

conclusionsDespite a higher prevalence of AMHR2, LHCGR, MTHFR, and SERPINE1 variations in the patients with poor ovarian response, it seems that these variations are not associated with the ovarian response.

Indexed as

Polymorphism, Single NucleotideAdultFemaleFertilization in VitroGenetic Predisposition to DiseaseGenotypeGonadotropinsHumansInfertility, FemaleIntracellular Signaling Peptides and ProteinsMethylenetetrahydrofolate Reductase (NADPH2)Nuclear ProteinsOvarian Hyperstimulation SyndromeOvarian ReserveOvulation InductionPlasminogen Activator Inhibitor 1GonadotropinsIntracellular Signaling Peptides and ProteinsLHCGR protein, humanMethylenetetrahydrofolate Reductase (NADPH2)MRFAP1 protein, humanMTHFR protein, humanNuclear ProteinsPlasminogen Activator Inhibitor 1Receptors, LHRNA, Long NoncodingSERPINE1 protein, humanAssisted reproductive technologyGenetic variationsInfertilityOvarian poor response

Identifiers

PMID34050449
PMCPMC8490577
OpenAlexW3165193242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.