Evidence map›Paper›PMID 34050417›Full record

ArticleBulletin of experimental biology and medicine2021

Effect of M2 Macrophage-Derived Soluble Factors on Proliferation and Apoptosis of SH-SY5Y Cells.

I M Rashchupkin, A A Maksimova, L V Sakhno, A A Ostanin, E Ya Shevela, E R Chernykh

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

I M RashchupkinResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. iwwwanbets@mail.ru.
A A MaksimovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
L V SakhnoResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
A A OstaninResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E Ya ShevelaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E R ChernykhResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Research Institute of Fundamental and Clinical Immunology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play the key role in the regulation of neuroregeneration. For evaluation of the neuroregenerative potential of M2 macrophages, we studied the effect of macrophages polarized with IL-4 (M2a (IL-4)) and by efferocytosis under conditions of serum deprivation (LS, Low Serum; M2(LS)) on proliferative activity and apoptosis of SH-SY5Y cells under conditions of deficiency of growth/serum factors. Conditioned media of both M2(LS) and M2a(IL-4) stimulated proliferation of SH-SY5Y cells. Moreover, soluble factors of M2(LS) and M2a(IL-4) reduced the degree of early apoptosis of SH-SY5Y cells and the protective effect of M2(LS) was observed at earlier terms of culturing. Our findings suggest that M2 macrophages have high neuroregenerative potential that is mediated through soluble factors and manifests itself both in stimulation of proliferation and inhibition of apoptosis of SH-SY5Y cells.

Indexed as

ApoptosisMacrophagesCell Line, TumorCell ProliferationCulture Media, ConditionedHumansPhagocytosisCulture Media, Conditionedapoptosishuman macrophagesneural stem cellsproliferation

Identifiers

PMID34050417
OpenAlexW3121140706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.