Evidence map›Paper›PMID 34050405›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity - initial experience and comparison to [

Christian Linz, Roman C Brands, Olivia Kertels, Alexander Dierks, Joachim Brumberg, Elena Gerhard-Hartmann, Stefan Hartmann, Andreas Schirbel, Sebastian Serfling, Yingjun Zhi and 5 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Role ofCancers · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. The comparative utility of FAPI-based PET radiotracers over [American journal of nuclear medicine and molecular imaging · 2024
    Review
  14. Diagnostic Accuracy of [Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  15. Review
  16. Article
  17. The performance ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Christian Linz *Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Roman C Brands *Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Olivia KertelsComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Alexander DierksComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Joachim BrumbergComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Elena Gerhard-HartmannComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Stefan HartmannDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Andreas SchirbelComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Sebastian SerflingComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Yingjun ZhiDepartment of Otorhinolaryngology, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
Andreas K BuckComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.
Alexander KüblerDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Julian HohmDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Constantin LapaComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany. constantin.lapa@uk-augsburg.de.ORCID http://orcid.org/0000-0001-7536-2207
Malte KircherComprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.ORCID https://orcid.org/0000-0003-4355-0881
Comprehensive Cancer Center Mainfranken · DEUniversitätsklinikum Würzburg · DEUniversity of Augsburg · DEUniversity Medical Center Freiburg · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWhile [

methodsTen consecutive, treatment-naïve patients (8 males, 2 females; mean age, 62 ± 9 years) with biopsy-proven OSCC underwent both whole-body [

results[

conclusionFAP-directed PET/CT in OSCC seems feasible. Future research to investigate its potential to improve patient staging is highly warranted.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsAgedFemaleFibroblastsFluorodeoxyglucose F18HumansLymph NodesMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyPositron Emission Tomography Computed TomographyQuinolinesRadiopharmaceuticals68Ga-FAPIFluorodeoxyglucose F18QuinolinesRadiopharmaceuticalsFibroblast activation proteinHead and neck cancerMolecular imagingPET

Identifiers

PMID34050405
PMCPMC8484183
OpenAlexW3165241559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.