Evidence map›Paper›PMID 34050328›Full record

ReviewNature reviews. Microbiology2021

Prevotella diversity, niches and interactions with the human host.

Adrian Tett, Edoardo Pasolli, Giulia Masetti, Danilo Ercolini, Nicola Segata

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 433 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
433citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

433 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Bridging the gap:Gut microbes · 2026
    Review
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  11. Comparative analysis of gut microbiota in incident and prevalent peritoneal dialysis patients with peritoneal fibrosis, correlations with peritoneal equilibration test data in the peritoneal fibrosis cohort.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
    Article
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  13. Journal of bacteriology · 2026
    Review
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373 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrian TettCentre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
Edoardo PasolliDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Giulia MasettiDepartment CIBIO, University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0002-8513-2509
Danilo ErcoliniDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy. danilo.ercolini@unina.it.ORCID http://orcid.org/0000-0003-3061-9560
Nicola SegataDepartment CIBIO, University of Trento, Trento, Italy. nicola.segata@unitn.it.ORCID http://orcid.org/0000-0002-1583-5794

Funding

Exploiting Public Metagenomic Data to Uncover Cancer-Microbiome RelationshipsR01CA230551 · NCI · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · PI Levi Waldron · 2020 to 2026
$3.9M
Exploiting public metagenomic data to uncover cancer-microbiome relationshipsU01CA230551 · NCI · GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY · PI WALDRON, LEVI · 2019 to 2019
$464k
NCI NIH HHS R01 CA230551NCI NIH HHS U01 CA230551
6 · The paper itself

Abstract

The genus Prevotella includes more than 50 characterized species that occur in varied natural habitats, although most Prevotella spp. are associated with humans. In the human microbiome, Prevotella spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of Prevotella species and strains in the human microbiome. These factors, along with the ecological relationship of Prevotella with other members of the microbiome, likely determine the extent of the contribution of Prevotella to human metabolism and health. Here we review the diversity, prevalence and potential connection of Prevotella spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of Prevotella spp. and the effects of the Western lifestyle and diet on the host-Prevotella symbiotic relationship in the context of maintaining human health.

Indexed as

MicrobiotaAutoimmune DiseasesBacteroidaceae InfectionsGenetic VariationHumansPhylogenyPrevotella

Identifiers

PMID34050328
PMCPMC11290707

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.