ArticleMucosal immunology2021
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa.
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Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract-the B Cell Side.Allergy · 2026Review
- Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseases.bioRxiv : the preprint server for biology · 2026Article
- Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop.International forum of allergy & rhinology · 2025Review
- Decoding the causal association between immune cells and three chronic respiratory diseases: Insights from a bi-directional Mendelian randomization study.BMC pulmonary medicine · 2025Article
- Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract.Immunity · 2025Article
- Prostaglandin E Receptor 2 (EP2) Dysregulation in Allergic Fungal Rhinosinusitis Nasal Polyp Epithelium.The Laryngoscope · 2025Article
- Anti-IL-4Ra therapy is superior to other biologic classes in treating allergic bronchopulmonary aspergillosis.The journal of allergy and clinical immunology. Global · 2025Article
- Liver-draining portal lymph node responds to enteric nematode infection by generating highly parasite-specific follicular T helper and B cell responses.Frontiers in immunology · 2025Article
- Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps.JCI insight · 2024Article
- Whence and wherefore IgE?Immunological reviews · 2024Review
- Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity.The Journal of allergy and clinical immunology · 2024Observational
- The causal role of immune cells on lung cancer: a bi-directional Mendelian randomization (MR) study.Aging · 2024Article
- Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease.The Journal of allergy and clinical immunology · 2024Article
- Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.Research (Washington, D.C.) · 2024Article
- A Review on Novel Therapeutic Modalities and Evidence-based Drug Treatments against Allergic Rhinitis.Current pharmaceutical design · 2024Review
- The origins and longevity of IgE responses as indicated by serological and cellular studies in mice and humans.Allergy · 2023Review
- Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.Mucosal immunology · 2023Article
- Evidence that High-Affinity IgE Can Develop in the Germinal Center in the Absence of an IgG1-Switched Intermediate.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- B Lineage Cells and IgE in Allergic Rhinitis and CRSwNP and the Role of Omalizumab Treatment.American journal of rhinology & allergy · 2023Review
- DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation.International journal of environmental research and public health · 2022Article
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Authors and funding
20 authors at 3 institutions in 1 country.
Alessia Corrado *Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Richard P Ramonell *Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Matthew C WoodruffDivision of Rheumatology, Department of Medicine, Emory University, Atlanta, GA, USA.
Christopher TiptonDivision of Rheumatology, Department of Medicine, Emory University, Atlanta, GA, USA.
Sarah WiseDepartment of Otolaryngology, Emory University, Atlanta, GA, USA.
Joshua LevyDepartment of Otolaryngology, Emory University, Atlanta, GA, USA.
John DelGaudioDepartment of Otolaryngology, Emory University, Atlanta, GA, USA.
Merin E KuruvillaDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Kelly R MaglioccaDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Deepak TomarDivision of Rheumatology, Department of Medicine, Emory University, Atlanta, GA, USA.
Swetha GarimallaSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Hao WuDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Sanjeev GumberYerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Chris FucileDepartment of Microbiology and Immunology, Informatics Institute, University of Alabama, Birmingham, AL, USA.
Greg GibsonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Alexander RosenbergDepartment of Microbiology and Immunology, Informatics Institute, University of Alabama, Birmingham, AL, USA.
Iñaki SanzDivision of Rheumatology, Department of Medicine, Emory University, Atlanta, GA, USA.
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA. f.e.lee@emory.edu.ORCID http://orcid.org/0000-0002-6133-5942
Emory University · USGeorgia Institute of Technology · USUniversity of Alabama at Birmingham · US
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MRegulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6MRegulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2MVirus-induced Cell Fate Decisions in Anti-Viral ImmunityU19AI109962 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2014 to 2018
$11.6MRole of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI LOONEY, RICHARD JOHN · 2010 to 2014
$10.8MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0MMolecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and SpleenU01AI141993 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2019 to 2026
$5.7MMolecular Analysis and Lineage Tracing of Influenza-Specific, Lung-Resident Memory B CellsR01AI152476 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2020 to 2025
$5.5MA Model System for the Study of Human B-cell ToleranceR37AI049660 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2010 to 2019
$3.7MUnderstanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7MPathogenesis of RSV disease in the ElderlyU01AI045969 · NIAID · UNIVERSITY OF ROCHESTER · PI WALSH, EDWARD E · 2004 to 2008
$2.5MCharacterization of a Novel Diagnostic Test for Pneumococcal InfectionR21AI094218 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2012 to 2013
$440kNCATS NIH HHS R43 TR000023NCATS NIH HHS UL1 TR002378NIAID NIH HHS HHSN266200500030CNIAID NIH HHS N01 AI050029NIAID NIH HHS P01 AI078907NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI152476NIAID NIH HHS R21 AI094218NIAID NIH HHS R21 AI109601NIAID NIH HHS R37 AI049660NIAID NIH HHS U01 AI045969NIAID NIH HHS U01 AI141993NIAID NIH HHS U19 AI109962NIAID NIH HHS U19 AI110483NIGMS NIH HHS T32 GM008490
Abstract
Increased IgE is a typical feature of allergic rhinitis. Local class-switch recombination has been intimated but B cell precursors and mechanisms remain elusive. Here we describe the dynamics underlying the generation of IgE-antibody secreting cells (ASC) in human nasal polyps (NP), mucosal tissues rich in ASC without germinal centers (GC). Using V
Indexed as
AdultAntibody FormationAntibody-Producing CellsB-Lymphocyte SubsetsComputational BiologyGene Expression ProfilingGerminal CenterHigh-Throughput Nucleotide SequencingHumansHypersensitivityImmunoglobulin Class SwitchingImmunoglobulin DImmunoglobulin EImmunoglobulin IsotypesImmunophenotypingNasal MucosaImmunoglobulin DImmunoglobulin EImmunoglobulin Isotypes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.