ArticleScientific reports2021
Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Non-Dipping Blood Pressure and Reduced Heart Rate Deceleration Capacities Are Associated With Malnutrition in Patients With Gastrointestinal Cancer.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Dairy Consumption and Risk of Cardiometabolic Diseases: A Prospective Cohort Study of the China Kadoorie Biobank.The Journal of nutrition · 2026Article
- Genome-Wide Association Study of Genetic Variants Associated with Serum Albumin Levels in Chinese Winter Sports Athletes.Biology · 2026Article
- Machine learning prediction model for early postoperative hypoalbuminemia after pulmonary surgery: a retrospective case-matched comparative study.Journal of thoracic disease · 2026Article
- Observational
- Associations of the C-reactive protein-albumin-lymphocyte index with all-cause and cardiovascular mortality among individuals with cardiovascular disease: evidence from the NHANES 2001-2010.BMC cardiovascular disorders · 2025Article
- Functional and prognostic impacts of serum albumin with thoracic arterial calcification among asymptomatic individuals.Scientific reports · 2024Article
- Serum albumin and white matter hyperintensities.Translational psychiatry · 2024Article
- Serum albumin and white matter hyperintensities.Research square · 2024Article
- Association between serum albumin concentration change trajectory and risk of hypertension: a cohort study in China.Frontiers in cardiovascular medicine · 2024Article
- Effects of Interaction betweenNutrients · 2023Article
- Analysis of the Value of the Blood Urea Nitrogen to Albumin Ratio as a Predictor of Mortality in Patients with Sepsis.Journal of inflammation research · 2022Article
- A Perfect Storm: Case of Chronic Albumin Loss, Multi-Morbidity and Antibiotic Resistance.Current health sciences journalArticle
- Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoalbuminemia is associated with vascular endothelial dysfunction and the development of chronic cardiovascular diseases. However, the relationship between serum albumin concentration and blood pressure changes remains controversial. Community-based longitudinal cohort data collected from Korean Genome and Epidemiology Study were used in this study. Hypoalbuminemia was defined as a serum albumin concentration of ≤ 4.0 g/dL. A total of 4325 participants were categorized into control (n = 3157) and hypoalbuminemia (n = 1168) groups. Serum albumin had a non-linear relationship with the risk of hypertension development. A genome-wide association study revealed 71 susceptibility loci associated with hypoalbuminemia. Among susceptibility loci, genetic variations at rs2894536 in LOC107986598 and rs10972486 in ATP8B5P were related to elevated blood pressure. Serum albumin (HR = 0.654, 95% CI 0.521-0.820) and polymorphisms of rs2894536 (HR = 1.176, 95% CI 1.015-1.361) and rs10972486 (HR = 1.152, 95% CI 1.009-1.316) were significant predictors of hypertension development. Increased albumin concentration instrumented by 2 hypoalbuminemia-associated SNPs (rs2894536 and rs10972486) was associated with decreased HRs for hypertension development (HR = 0.762, 95% CI 0.659-0.882 and HR = 0.759, 95% CI 0.656-0.878). Our study demonstrated that genetically determined hypoalbuminemia is a significant predictor of incipient hypertension.
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