ArticleNature communications2021
Restoration of energy homeostasis by SIRT6 extends healthy lifespan.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
120 citing papers in PubMed, 188 citations in OpenAlex.
- Genetic links between multimorbidity and human aging.GeroScience · 2026Article
- SIRT6 activator MDL-800 alleviates periodontal inflammation by inhibiting AIM2 pathway.Acta pharmaceutica Sinica. B · 2026Article
- Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion.International journal of molecular sciences · 2026Article
- Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis.bioRxiv : the preprint server for biology · 2026Article
- Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.GeroScience · 2026Article
- Mitigation of renal tubular injury by SIRT6 may improve individual outcomes in diabetic kidney disease-potential mechanisms involving epigenetic repression of inflammatory responses.Journal of advanced research · 2026Article
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment.Autophagy · 2026Article
- Mitigating nucleus pulposus cell senescence in intervertebral disk degeneration: the role of nodakenin in SIRT6 and PINK1/Parkin-associated mitophagy signaling.Cellular & molecular biology letters · 2026Article
- Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance.Research square · 2026Article
- Beyond deacetylation: crosstalk mechanisms and context-dependent regulation of sirtuin non-classical enzymatic functions in disease.Molecular medicine (Cambridge, Mass.) · 2026Review
- SIRT6 overexpression counteracts chromatin aging in the male murine liver.Nature communications · 2026Article
- Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.bioRxiv : the preprint server for biology · 2026Article
- Role of Sirtuin 6 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Current issues in molecular biology · 2026Review
- Deciphering the role of SIRT6 in suppressing the AMPK-mTOR-TFEB axis: regulation of autophagy activation in HCC.Cancer gene therapy · 2026Article
- Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.Cell reports · 2026Article
- Evaluation of Molecular Responses and Longevity Markers inInternational journal of molecular sciences · 2026Article
- Dissecting the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling.NPJ precision oncology · 2026Article
- No effect of pyrroloquinoline quinone on mouse body weight and energy metabolism with the concomitant increase in mitochondrial biogenesis and antioxidant ability.Metabolism open · 2026Article
- Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations.bioRxiv : the preprint server for biology · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 3 countries.
A Roichman *The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.ORCID http://orcid.org/0000-0001-9538-0103
S Elhanati *The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
M A AonTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
I AbramovichTechnion Integrated Cancer Center, Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel.
A Di FrancescoTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
Y ShaharThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
M Y AviviThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
M ShurgiThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
A RubinsteinThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Y WiesnerThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.ORCID http://orcid.org/0000-0002-4845-9131
A ShuchamiThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.ORCID http://orcid.org/0000-0002-5750-1215
Z PetroverThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
I Lebenthal-LoingerThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
O YaronThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
A LyashkovTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
C Ubaida-MohienTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
Y KanfiThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
B LerrerThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
P J Fernández-MarcosMetabolic Syndrome Group-BIOPROMET, Madrid Institute for Advanced Studies-IMDEA Food, CEI UAM + CSIC, Madrid, Spain.ORCID http://orcid.org/0000-0003-3515-4125
M SerranoInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.ORCID http://orcid.org/0000-0001-7177-9312
E GottliebTechnion Integrated Cancer Center, Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel.ORCID http://orcid.org/0000-0002-9770-0956
R de CaboTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3354-2442
H Y CohenThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. Haim.Cohen@biu.ac.il.
Bar-Ilan University · ILNational Institute on Aging · USTechnion – Israel Institute of Technology · ILInstitució Catalana de Recerca i Estudis Avançats · ESMadrid Institute for Advanced Studies · ES
Funding
Calorie restriction and agingZIAAG000368 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$6.9MNRF2 interactions with SIRT1 and its role on caloric restrictionZIAAG000361 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2024
$5.3MAging and CR effects on the Plasma Membrane Redox SystemZIAAG000362 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$5.0MAbstract
Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD
Indexed as
AnimalsDisease Models, AnimalEnergy MetabolismFemaleFrailtyGene Expression RegulationGluconeogenesisGlucoseHealthy AgingHumansLiverLongevityMaleMiceMice, TransgenicSirtuin 1GlucoseSirt1 protein, mouseSirt6 protein, mouseSirtuin 1Sirtuins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.