Evidence map›Paper›PMID 34050123›Full record

SynthesisTranslational psychiatry2021

Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis.

Jeffrey D Voigt, Andrew F Leuchter, Linda L Carpenter

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05811104 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant Depression: A Randomized Double-Blind Sham-controlled Pilot Study

TypeinterventionalSponsorUniversity of CalgaryRan2023 to 2025Enrolled40ConditionsTreatment Resistant DepressionArmsSequential bilateral theta burst stimulation
NCT06895863 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Copenhagen Magnetic Personalized Accelerated Brain Circuit Therapy (CoMPACT) Trial

TypeinterventionalSponsorDanish Research Centre for Magnetic ResonanceRan2025 to 2028Enrolled78ConditionsTreatment Resistant DepressionArmsMagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Device: MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Sham stimulation of the MagVenture MagPro XP Orange Edition Prototype flipping the active side of the MagVenture Cool-B65 coil
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Accelerated sequential bilateral theta-burst stimulation in major depression: an open trial.European archives of psychiatry and clinical neuroscience · 2024
    Trial
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Intermittent theta burst stimulation vs. high-frequency repetitive transcranial magnetic stimulation for post-stroke dysfunction: a Bayesian model-based network meta-analysis of RCTs.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  18. The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jeffrey D Voigt99 Glenwood Road, Ridgewood, NJ, USA. meddevconsultant@aol.com.ORCID 0000-0002-1755-8612
Andrew F LeuchterUniversity of California Los Angeles (UCLA), Neuromodulation Division, Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA.
Linda L CarpenterBrown University Department of Psychiatry and Human Behavior, Butler Hospital TMS Clinic and Neuromodulation Research Facility, Los Angeles, USA.
Brown University · USRidgewood Public Schools · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with major depressive disorder (MDD) may be refractory to or have contraindications that preclude treatment with antidepressant pharmacotherapies. Alternative therapies such as repetitive transcranial magnetic stimulation (rTMS) continue to evolve, and include theta burst stimulation (TBS), which has advantages over conventional rTMS. The aim of this study was to identify and meta-analyze efficacy data from all randomized controlled trials (RCTs) investigating TBS as a treatment for MDD. Published reports of RCTs (January 1, 2010 to October 23, 2020) were identified via systematic searches in computerized databases, followed by review of individual reports for inclusion. Inclusion criteria included primary diagnosis of MDD ≥ 1 week duration of therapy with ≥10 sessions, and treatment with any form of TBS. The Cochrane GRADE methodology and PRISMA criteria were used for evaluation of individual trials. Data from ten RCTs were included, representing 667 patients. Of these, 8 RCTs compared TBS to sham treatment and one compared TBS to standard rTMS (i.e., high frequency stimulation over left dorsolateral prefrontal cortex [HFL]). Quality of evidence assessment yielded high confidence in the finding of TBS being superior to sham on response measured by the Hamilton Depression Rating Scale (HRSD) (RR = 2.4; 95% CI: 1.27 to 4.55; P = 0.007; I

Indexed as

Depressive Disorder, Treatment-ResistantMajor Depressive DisorderAntidepressive AgentsHumansPrefrontal CortexRandomized Controlled Trials as TopicTranscranial Magnetic StimulationTreatment OutcomeAntidepressive Agents

Identifiers

PMID34050123
PMCPMC8163818
OpenAlexW3165230137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.