Evidence map›Paper›PMID 34050026›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Chemotactic movement of a polarity site enables yeast cells to find their mates.

Debraj Ghose, Katherine Jacobs, Samuel Ramirez, Timothy Elston, Daniel Lew

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Role of Gα-MAPK interaction in mating ofMolecular biology of the cell · 2025
    Article
  7. Article
  8. Iron necessity for chlamydospore germination in Fusarium oxysporum f. sp. cubense TR4.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  9. Article
  10. Mechanism of commitment to a mating partner inMolecular biology of the cell · 2022
    Article
  11. Article
  12. Article
  13. Orientation of Cell Polarity by Chemical Gradients.Annual review of biophysics · 2022
    Review
  14. Article
  15. Chemotactic movement of a polarity site enables yeast cells to find their mates.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Debraj GhoseComputational Biology and Bioinformatics, Duke University, Durham, NC 27710.ORCID 0000-0002-2355-8491
Katherine JacobsDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-6828-0828
Samuel RamirezDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Timothy ElstonDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-4601-2117
Daniel LewDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710; daniel.lew@duke.edu.ORCID 0000-0001-7482-3585
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · USDuke University · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Studies on cell polarity, chemotropism, and cell cycle controlR35GM122488 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANIEL J LEW · 2017 to 2026
$6.9M
Mathematical modeling of cellular signaling systemsR35GM127145 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Timothy C Elston · 2018 to 2026
$3.9M
Genetics and Genomics Training GrantT32GM136627 · NIGMS · DUKE UNIVERSITY · PI ALLISON E ASHLEY-KOCH · 2020 to 2026
$3.1M
Gradient Tracking and ChemotropismR01GM103870 · NIGMS · DUKE UNIVERSITY · PI ELSTON, TIMOTHY C, LEW, DANIEL J · 2013 to 2016
$1.8M
NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R01 GM103870NIGMS NIH HHS R35 GM122488NIGMS NIH HHS R35 GM127145NIGMS NIH HHS T32 GM136627
6 · The paper itself

Abstract

How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical gradients to orient growth or movement is poorly understood. We address this question using

Indexed as

Cell PolarityChemotaxisComputational BiologySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiae Proteinscell polaritychemotropismmodelingpheromoneyeast

Identifiers

PMID34050026
PMCPMC8179161
OpenAlexW3165232703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.