Evidence map›Paper›PMID 34050022›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The history and evolution of the Denisovan-

Xinjun Zhang, Kelsey E Witt, Mayra M Bañuelos, Amy Ko, Kai Yuan, Shuhua Xu, Rasmus Nielsen, Emilia Huerta-Sanchez

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. TheScience (New York, N.Y.) · 2025
    Article
  10. Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Animals : an open access journal from MDPI · 2025
    Article
  18. Article
  19. Review
  20. Computational Genomics and Its Applications to Anthropological Questions.American journal of biological anthropology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Xinjun ZhangDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095.ORCID 0000-0003-1298-3545
Kelsey E WittDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912.ORCID 0000-0002-3242-2123
Mayra M BañuelosDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912.ORCID 0000-0002-6292-6269
Amy KoDepartment of Integrative Biology, University of California, Berkeley, CA 94720.
Kai YuanCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.
Shuhua XuCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0002-1975-1002
Rasmus NielsenDepartment of Integrative Biology, University of California, Berkeley, CA 94720.
Emilia Huerta-SanchezDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912; emilia_huerta-sanchez@brown.edu.ORCID 0000-0002-1506-5494
Brown University · USChinese Academy of Sciences · CNUniversity of California, Berkeley · USUniversity of California, Los Angeles · USUniversity of Copenhagen · DK

Funding

Population genomics of the selective effects of new mutationsR35GM119856 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOHMUELLER, KIRK · 2016 to 2025
$3.4M
Characterizing modes of natural selection via diverse ancient and modern samplesR35GM128946 · NIGMS · BROWN UNIVERSITY · PI Emilia Huerta-Sanchez · 2018 to 2026
$3.1M
Predoctoral Training Program in Biological Data Science at Brown UniversityT32GM128596 · NIGMS · BROWN UNIVERSITY · PI RAMACHANDRAN, SOHINI, SANDSTEDE, BJORN · 2018 to 2022
$1.5M
NIGMS NIH HHS R35 GM119856NIGMS NIH HHS R35 GM128946NIGMS NIH HHS T32 GM128596
6 · The paper itself

Abstract

Recent studies suggest that admixture with archaic hominins played an important role in facilitating biological adaptations to new environments. For example, interbreeding with Denisovans facilitated the adaptation to high-altitude environments on the Tibetan Plateau. Specifically, the

Indexed as

Evolution, MolecularHaplotypesAdaptation, PhysiologicalAltitudeBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1HumansTibetBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1adaptationadmixturearchaic introgressionhigh altitudenatural selection

Identifiers

PMID34050022
PMCPMC8179186
OpenAlexW3165191878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.