Evidence map›Paper›PMID 34049989›Full record

ArticleeNeuro

EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth.

Michael G Mariscal, April R Levin, Laurel J Gabard-Durnam, Wanze Xie, Helen Tager-Flusberg, Charles A Nelson

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  8. Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael G MariscalDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
April R LevinDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115 april.levin@childrens.harvard.edu.ORCID 0000-0003-4192-4720
Laurel J Gabard-DurnamDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215.
Wanze XieDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215.
Helen Tager-FlusbergDepartment of Psychological and Brain Sciences, Boston University, Boston, MA 02215.
Charles A NelsonDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215.
Boston Children's Hospital · USBoston University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Neurobehavioral Research on Infants at Risk for SLI and AutismR01DC010290 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, CHARLES ALEXANDER, TAGER-FLUSBERG, HELEN · 2009 to 2020
$7.5M
Infants at Risk for Autism Spectrum Disorders or Language DelayR21DC008637 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TAGER-FLUSBERG, HELEN B. · 2006 to 2007
$439k
NICHD NIH HHS P50 HD105351NIDCD NIH HHS R01 DC010290NIDCD NIH HHS R21 DC008637
6 · The paper itself

Abstract

Phase-amplitude coupling (PAC), the coupling of the phase of slower electrophysiological oscillations with the amplitude of faster oscillations, is thought to facilitate dynamic integration of neural activity in the brain. Although the brain undergoes dramatic change and development during the first few years of life, how PAC changes through this developmental period has not been extensively studied. Here, we examined PAC through electroencephalography (EEG) data collected during an awake, eyes-open EEG collection paradigm in 98 children between the ages of three months and three years. We employed non-parametric clustering methods to identify areas of significant PAC across a range of frequency pairs and electrode locations, and examined how PAC strength and phase preference develops in these areas. We found that PAC, primarily between the α-β and γ frequencies, was positively correlated with age from early infancy to early childhood (

Indexed as

BrainElectroencephalographyChildChild, PreschoolComputer SimulationHumansInfantconnectivitycross frequencydevelopmentEEGphase-amplitude couplingphase preference

Identifiers

PMID34049989
PMCPMC8225408
OpenAlexW3164219135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.