Evidence map›Paper›PMID 34049986›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Dynamic Amyloid PET: Relationships to

Fabio Raman, Yu-Hua Dean Fang, Sameera Grandhi, Charles F Murchison, Richard E Kennedy, John C Morris, Parinaz Massoumzadeh, Tammie Benzinger, Erik D Roberson, Jonathan McConathy

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabio RamanDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Yu-Hua Dean FangDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Sameera GrandhiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Charles F MurchisonAlzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, Alabama.
Richard E KennedyAlzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, Alabama.
John C MorrisDepartment of Neurology, Washington University in St. Louis School of Medicine, St. Louis, Missouri; and.
Parinaz MassoumzadehMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Tammie BenzingerMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Erik D RobersonAlzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, Alabama.
Jonathan McConathyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama; jmcconathy@uabmc.edu.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
DIAN-TU Next Generation Prevention Trial - Data Request Management SupplementR01AG053267 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2017 to 2023
$34.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Dominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Validation of Online Methods to Predict and Monitor Cognitive DeclineRF1AG059009 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2018 to 2018
$6.2M
PET Imaging of Neuroinflammation in Genetic Alzheimer's DiseaseR01AG052550 · NIA · WASHINGTON UNIVERSITY · PI Beau M Ances, Tammie Lee Smith Benzinger · 2018 to 2026
$4.2M
Quantification of Neuroinflammation inAlzheimer's Disease Using Diffusion BasisSpectrum ImagingR01AG054567 · NIA · WASHINGTON UNIVERSITY · PI BENZINGER, TAMMIE LEE SMITH, WANG, YONG · 2017 to 2021
$3.6M
NCATS NIH HHS UL1 TR002345NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068024NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG052550NIA NIH HHS R01 AG053267NIA NIH HHS RF1 AG059009NIA NIH HHS U19 AG032438NIA NIH HHS UF1 AG032438NIGMS NIH HHS T32 GM008361NIH HHS S10 OD025214
6 · The paper itself

Abstract

Measuring amyloid and predicting tau status using a single amyloid PET study would be valuable for assessing brain AD pathophysiology. We hypothesized that early-frame amyloid PET (efAP) correlates with the presence of tau pathology because the initial regional brain concentrations of radioactivity are determined primarily by blood flow, which is expected to be decreased in the setting of tau pathology.

Indexed as

Alzheimer DiseaseAmyloidosisCognitive DysfunctionTauopathiesAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsCarbolinesHumansPositron-Emission Tomographytau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsCarbolinestau Proteins18F-florbetapir PET18F-flortaucipir PETearly-frame amyloid PETearly-phase PET

Identifiers

PMID34049986
PMCPMC8805772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.