ArticleThe European respiratory journal2021
AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
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Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
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- Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway.International journal of biological sciences · 2024Article
- Targeting the AMPK/Nrf2 Pathway: A Novel Therapeutic Approach for Acute Lung Injury.Journal of inflammation research · 2024Review
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- Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway.BMC pharmacology & toxicology · 2023Article
- Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats.Neurochemical research · 2023Article
- Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway.Microbiology spectrum · 2023Article
- The Role of Histone Deacetylases in Acute Lung Injury-Friend or Foe.International journal of molecular sciences · 2023Review
- The SARS-CoV-2 spike S1 protein induces global proteomic changes in ATII-like rat L2 cells that are attenuated by hyaluronan.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- AMPK Activation: Respiratory Panacea?American journal of respiratory cell and molecular biology · 2023Article
- AMPK-driven Macrophage Responses Are Autophagy Dependent in Experimental Bronchopulmonary Dysplasia.American journal of respiratory cell and molecular biology · 2023Article
- AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics.Frontiers in pharmacology · 2022Article
- Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function.Frontiers in pharmacology · 2022Review
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Authors and funding
12 authors at 1 institution in 1 country.
Israr AhmadDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Adam MolyvdasDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ming-Yuan JianDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ting ZhouDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Amie M TraylorDivision of Nephrology, Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Huachun CuiDivision of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Gang LiuDivision of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-6999-7633
Weifeng SongDept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Anupam AgarwalDivision of Nephrology, Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Tamas JillingDivision of Neonatology, Dept of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-6200-3851
Saurabh AggarwalDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sadis MatalonDivision of Molecular and Translational Biomedicine, Dept of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA smatalon@uabmc.edu.
University of Alabama at Birmingham · US
Funding
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1MNational Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6MUAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MProgram on cellular metabolism and lung fibrosisR35HL135830 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, GANG · 2017 to 2023
$5.2MHuman Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5MBromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9MCIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7MUAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and ResearchK12HL143958 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HEATH, SONYA L · 2018 to 2022
$1.6MIdentification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicityU01ES033265 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2023
$1.3MCentral Role of Heme Oxygenase in Reversing Bromine Morbidity and MortalityR21ES025423 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM, MATALON, SADIS · 2014 to 2015
$771kMitigation of Chlorine Injury to MitochondriaR21ES032956 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2021 to 2022
$422kNCATS NIH HHS UL1 TR003096NHLBI NIH HHS K12 HL143958NHLBI NIH HHS R35 HL135830NIAID NIH HHS P30 AI027767NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK059600NIEHS NIH HHS R21 ES025423NIEHS NIH HHS R21 ES032956NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697NIEHS NIH HHS U01 ES033265
Abstract
aimWe investigated the mechanisms by which N1-(β-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase (AMPK), decreases lung injury and mortality when administered to mice post exposure to bromine gas (Br
methodsWe exposed male C57BL/6 mice and heme oxygenase-1 (HO-1)-deficient (HO-1
resultsThere was a marked downregulation of phosphorylated AMPK and LKB1 in lung tissues and in L2 and H441 cells post exposure. AICAR increased survival in C57BL/6 but not in HO-1
conclusionsOur data indicate that the primary mechanism for the protective action of AICAR in toxic gas injury is the upregulation of lung HO-1 levels.
Indexed as
Acute Lung InjuryAMP-Activated Protein KinasesAminoimidazole CarboxamideAnimalsHeme Oxygenase-1MaleMiceMice, Inbred C57BLRatsRibonucleotidesAICA ribonucleotideAminoimidazole CarboxamideAMP-Activated Protein KinasesHeme Oxygenase-1Ribonucleotides
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