Evidence map›Paper›PMID 34049948›Full record

ArticleThe European respiratory journal2021

A prospective multicentre diagnostic accuracy study for the Truenat tuberculosis assays.

Adam Penn-Nicholson, Sivaramakrishnan N Gomathi, Cesar Ugarte-Gil, Abyot Meaza, Evelyn Lavu, Pranav Patel, Bandana Choudhury, Camilla Rodrigues, Sarabjit Chadha, Mubin Kazi and 15 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 9 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 9 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 6 countries.

Adam Penn-NicholsonFIND, Geneva, Switzerland adam.penn-nicholson@finddx.org.
Sivaramakrishnan N GomathiNational Institute for Research in Tuberculosis, Chennai, India.
Cesar Ugarte-GilInstituto de Medicina Tropical Alexander von Humboldt, Lima, Peru.
Abyot MeazaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Evelyn LavuCentral Public Health Laboratory, Port Moresby, Papua New Guinea.
Pranav PatelState TB Demonstration and Training Centre, Ahmedabad, India.
Bandana ChoudhuryIntermediate Reference Laboratory, Guwahati, India.
Camilla RodriguesPD Hinduja Hospital, Mumbai, India.
Sarabjit ChadhaFIND - India, New Delhi, India.
Mubin KaziPD Hinduja Hospital, Mumbai, India.
Aurélien MacéFIND, Geneva, Switzerland.
Pamela NabetaFIND, Geneva, Switzerland.
Catharina BoehmeFIND, Geneva, Switzerland.
Raman R GangakhedkarIndian Council of Medical Research, New Delhi, India.
Sanjay SarinFIND - India, New Delhi, India.
Ephrem TesfayeEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Eduardo GotuzzoInstituto de Medicina Tropical Alexander von Humboldt, Lima, Peru.
Philipp du CrosBurnet Institute, Melbourne, Australia.
Srikanth TripathyNational Institute for Research in Tuberculosis, Chennai, India.
Morten RuhwaldFIND, Geneva, Switzerland.
Manjula SinghIndian Council of Medical Research, New Delhi, India.
Claudia M DenkingerFIND, Geneva, Switzerland.
Samuel G SchumacherFIND, Geneva, Switzerland.ORCID 0000-0002-6136-206X
Truenat Trial Consortium
Members of the Truenat Trial Consortium:
FIND · CHEthiopian Public Health Institute · ETIndian Council of Medical Research · INNational Institute of Research in Tuberculosis · INP. D. Hinduja Hospital and Medical Research Centre · INBurnet Institute · AUUniversidad Peruana Cayetano Heredia · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBringing reliable and accurate tuberculosis (TB) diagnosis closer to patients is a key priority for global TB control. Molbio Diagnostics have developed the Truenat point-of-care molecular assays for detection of TB and rifampicin (RIF) resistance.

methodsWe conducted a prospective multicentre diagnostic accuracy study at 19 primary healthcare centres and seven reference laboratories in Peru, India, Ethiopia and Papua New Guinea to estimate the diagnostic accuracy of the point-of-care Truenat MTB, MTB Plus and MTB-RIF Dx assays for pulmonary TB using culture and phenotypic drug susceptibility testing as the reference standard, compared with Xpert MTB/RIF or Ultra.

resultsOf 1807 enrolled participants with TB signs/symptoms, 24% were culture-positive for

conclusionWe found the performance of Molbio's Truenat MTB, MTB Plus and MTB-RIF Dx assays to be comparable to that of the Xpert MTB/RIF assay. Performing the Truenat tests in primary healthcare centres with very limited infrastructure was feasible. These data supported the development of a World Health Organization policy recommendation of the Molbio assays.

Indexed as

Antibiotics, AntitubercularMycobacterium tuberculosisTuberculosisDrug Resistance, BacterialHumansMicrobial Sensitivity TestsProspective StudiesSensitivity and SpecificitySputumAntibiotics, Antitubercular

Identifiers

PMID34049948
PMCPMC8607906
OpenAlexW3164737901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.