Evidence map›Paper›PMID 34049896›Full record

ArticleBMJ case reports2021

Sarcoid-like reaction: a unique response to immunotherapy in malignant melanoma.

Taha Khalid, Asma Patil, Alina Ahmed, Ala Yousif

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Taha KhalidOncology, Sligo University Hospital, Sligo, Ireland tahakhalid@outlook.ie.ORCID http://orcid.org/0000-0002-5269-1160
Asma PatilOncology, Sligo University Hospital, Sligo, Ireland.
Alina AhmedMedicine, Kingsbridge Private Hospital, Sligo, Ireland.
Ala YousifOncology, Sligo University Hospital, Sligo, Ireland.
Sligo University Hospital · IEKingsbridge Private Hospital Sligo · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, immunotherapy has revolutionised the treatment landscape for oncology patients with improved survival rates in cancers which previously had a dismissal prognosis. These agents target specific pathways of inhibition such as programmed cell death -1 (PD-1), PD ligand-1 and cytotoxic T-lymphocyte-associated antigen 4 resulting in stimulation of T cell activity. This results in enabling an individual's own immune system to fight against cancer, a different modality of treatment when compared with traditional chemotherapy. While attacking the tumour cells, there is an increased chance of host tissue immune reactions.We report a case of a patient who received immunotherapy for metastatic malignant melanoma. During the course of the treatment, development of a sarcoid-like reaction was histologically confirmed in the mediastinal lymph nodes. The patient had no respiratory symptoms and continued on the immunotherapy treatment with good clinical and radiological response.

Indexed as

MelanomaSarcoidosisSkin NeoplasmsHumansImmunotherapyProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 Receptorimmunologyrespiratory systemskin cancer

Identifiers

PMID34049896
PMCPMC8166615
OpenAlexW3164966096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.