ArticleMicrobiome2021
The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Impact of bariatric surgery on gut microbiota in obese patients: A systematic review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Pooled it
- THE INTESTINAL MICROBIOME IN PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022 · on this mapPooled it
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- The Urogenital Microbiome-Metabolic Interface in Postmenopausal Recurrent Urinary Tract Infection: Estrogen Deficiency, Diabetes, Obesity, and Microbial Reservoirs.Journal of clinical medicine · 2026Review
- Higher BMI is associated with vaginal microbiome alterations in women with PCOS.Reproduction & fertility · 2026Article
- Vaginal microbiota in assisted reproduction: determinants, dynamics, and impact on clinical outcomes.Frontiers in microbiology · 2026Review
- Association between body mass index and the risk of bacterial vaginosis: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- The Vaginal Microbiome and Reproductive Health in Adolescents and Adults.Journal of pediatric and adolescent gynecology · 2025Review
- Population-level analyses identify host and environmental variables influencing the vaginal microbiome.Signal transduction and targeted therapy · 2025Article
- Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women.Frontiers in cellular and infection microbiology · 2025Article
- An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.International journal of molecular sciences · 2024Observational
- Gut flora influences the hypothalamic-gonadal axis to regulate the pathogenesis of obesity-associated precocious puberty.Scientific reports · 2024Article
- Article
- Diet influences community dynamics following vaginal group B streptococcus colonization.Microbiology spectrum · 2024Article
- Association between body mass index and prevalence of bacterial vaginosis: Results from the NHANES 2001-2004 study.PloS one · 2024Article
- Diverse vaginal microbiota in healthy Japanese women: a combined relative and quantitative analyses.Frontiers in cellular and infection microbiology · 2024Article
- Optimizing surgical outcomes for elderly gallstone patients with a high body mass index using enhanced recovery after surgery protocol.World journal of gastrointestinal surgery · 2023Article
- Cycle Biodynamics of Women's Microbiome in the Urinary and Reproductive Systems.Journal of clinical medicine · 2023Review
- The Vaginal Microbiome in Health and Disease-What Role Do Common Intimate Hygiene Practices Play?Microorganisms · 2023Review
- Changes in the composition of gut and vaginal microbiota in patients with postmenopausal osteoporosis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundObesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammation and bariatric surgery.
methodsVaginal bacterial composition assessed by high-throughput sequencing of bacterial 16S rRNA genes and local cytokine levels measured using a multiplexed Magnetic Luminex Screening Assay were compared between 67 obese and 42 non-obese women. We further assessed temporal changes in the microbiota and cytokines in a subset of 27 women who underwent bariatric surgery.
resultsThe bacterial component of the vaginal microbiota in obese women was characterised by a lower prevalence of a Lactobacillus-dominant VMB and higher prevalence of a high diversity (Lactobacillus spp., and Gardnerella- spp. depleted) VMB, compared with non-obese subjects (p<0.001). Obese women had higher relative abundance of Dialister species (p<0.001), Anaerococcus vaginalis (p=0.021), and Prevotella timonensis (p=0.020) and decreased relative abundance of Lactobacillus crispatus (p=0.014). Local vaginal IL-1β, IL-4, IL-6, IL-8, IFNγ, MIP-1α and TNFα levels were all higher among obese women, however, only IL-1β and IL-8 correlated with VMB species diversity. In a subset of obese women undergoing bariatric surgery, there were no significant overall differences in VMB following surgery; however, 75% of these women remained obese at 6 months. Prior to surgery, there was no relationship between body mass index (BMI) and VMB structure; however, post-surgery women with a Lactobacillus-dominant VMB had a significantly lower BMI than those with a high diversity VMB.
conclusionsObese women have a significantly different vaginal microbiota composition with increased levels of local inflammation compared to non-obese women. Bariatric surgery does not change the VMB; however, those with the greatest weight loss 6-month post-surgery are most likely to have a Lactobacillus-dominant VMB. Video abstract.
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Registered trials
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