Evidence map›Paper›PMID 34049578›Full record

ArticleBMC research notes2021

Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma.

Ridwan Dwi Saputro, Hanggoro Tri Rinonce, Yayuk Iramawasita, Muhammad Rasyid Ridho, Maria Fransiska Pudjohartono, Sumadi Lukman Anwar, Kunto Setiaji, Teguh Aryandono

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ridwan Dwi SaputroDepartment of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman, Yogyakarta, Indonesia.
Hanggoro Tri RinonceDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman , Yogyakarta, Indonesia. hanggoro_rinonce@ugm.ac.id.ORCID http://orcid.org/0000-0003-1266-451X
Yayuk IramawasitaDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman , Yogyakarta, Indonesia.
Muhammad Rasyid RidhoDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman , Yogyakarta, Indonesia.
Maria Fransiska PudjohartonoDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman , Yogyakarta, Indonesia.
Sumadi Lukman AnwarDepartment of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman, Yogyakarta, Indonesia.
Kunto SetiajiDepartment of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman, Yogyakarta, Indonesia.
Teguh AryandonoDepartment of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital , Sleman, Yogyakarta, Indonesia.
Universitas Gadjah Mada · ID

Funding

Universitas Gadjah Mada 2607/UN1/DITLIT/DIT-LIT/PT/2020
6 · The paper itself

Abstract

objectiveBiomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue with clinicopathologic characteristics and survival in Indonesian primary nodular melanoma patients.

resultsThirty-one tissue samples were obtained; two were excluded from survival analysis due to Breslow depth of less than 4 mm. The median survival of upregulated and normoregulated PD-L1-patients were 15.800 ± 2.345 and 28.945 ± 4.126 months, respectively. However, this difference was not significant statistically (p = 0.086). Upregulated and normoregulated NKG2A patients differed very little in median survival time (25.943 ± 7.415 vs 26.470 ± 3.854 months; p = 0.981). Expression of PD-L1 and NKG2A were strongly correlated (r

Indexed as

MelanomaSkin NeoplasmsB7-H1 AntigenHumansIndonesiaNK Cell Lectin-Like Receptor Subfamily CPrognosisB7-H1 AntigenCD274 protein, humanKLRC1 protein, humanNK Cell Lectin-Like Receptor Subfamily CIndonesiaMelanomaNKG2APD-L1Skin cancer

Identifiers

PMID34049578
PMCPMC8161664
OpenAlexW3136318315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.