Evidence map›Paper›PMID 34049502›Full record

ArticleBMC nephrology2021

Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study.

Helen L MacLaughlin, Mindy Pike, Nicholas M Selby, Edward Siew, Vernon M Chinchilli, Andrew Guide, Thomas G Stewart, Jonathan Himmelfarb, Alan S Go, Chirag R Parikh and 5 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 3 countries.

Helen L MacLaughlinQueensland University of Technology, School of Exercise and Nutrition Sciences, Victoria Park Road, Kelvin Grove, QLD, Australia. h.maclaughlin@qut.edu.au.
Mindy PikeDivision of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA.
Nicholas M SelbyCentre for Kidney Research and Innovation, University of Nottingham, Derby, UK.
Edward SiewDivision of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA.
Vernon M ChinchilliDivision of Biostatistics and Informatics, Pennsylvania State University, Hershey, PA, USA.
Andrew GuideDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Thomas G StewartDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jonathan HimmelfarbDivision of Nephrology, University of Washington, Seattle, WA, USA.
Alan S GoKaiser Permanente Northern California, Oakland, CA, USA.
Chirag R ParikhDivision of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Nasrollah GhahramaniDivision of Nephrology, Department of Medicine, Penn State College of Medicine, Hershey, PA, USA.
James KaufmanRenal Section, Veterans Affairs New York Harbor Health Care System and New York University School of Medicine, New York, NY, USA.
T Alp IkizlerDivision of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA.
Cassianne Robinson-CohenDivision of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA.
ASSESS-AKI Study Investigators
Kaiser Permanente · USPennsylvania State University · USUniversity of Nottingham · GBVanderbilt University · USVanderbilt University Medical Center · USVA NY Harbor Healthcare System · USJohns Hopkins University · USQueensland University of Technology · AURoyal Brisbane and Women's Hospital · AU

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genetic Determinants of Outcomes in Acute Kidney InjuryU01DK084012 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, WURFEL, MARK M · 2010 to 2019
$6.2M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
NCATS NIH HHS TL1 TR002244NCATS NIH HHS UL1 TR001863NIDDK NIH HHS U01 DK084012
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI.

methodsThis prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes status, age, pre-existing CKD, cardiovascular disease status and intensive care unit admission, and stratified by study center. Body mass index (BMI) was added as an interaction term to examine effect modification by body size.

resultsThe cohort included 769 participants with AKI and 769 matched controls. After median follow-up of 4.3 years, among AKI survivors, the rate of the combined CKD outcome was 84.7 per1000-person-years with BMI ≥30 kg/m

conclusionsIn this post-hospitalization cohort, we found no evidence for obesity modifying the association between AKI and development or progression of CKD.

Indexed as

Body Mass IndexAcute Kidney InjuryAgedDisease ProgressionFemaleHumansMaleMiddle AgedObesityProspective StudiesRenal Insufficiency, ChronicBody mass index (BMI)KidneyMortalityObesity

Identifiers

PMID34049502
PMCPMC8161937
OpenAlexW3165871129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.