Evidence map›Paper›PMID 34049498›Full record

ArticleJournal of neurodevelopmental disorders2021

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I.

Jannath Begum-Ali, Anna Kolesnik-Taylor, Isabel Quiroz, Luke Mason, Shruti Garg, Jonathan Green, Mark H Johnson, Emily J H Jones, STAARS and EDEN Teams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  13. Loss ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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  16. Neural detection of changes in amplitude rise time in infancy.Developmental cognitive neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jannath Begum-Ali *Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK. jannath.begum@bbk.ac.uk.
Anna Kolesnik-Taylor *Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK.
Isabel QuirozCentre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK.
Luke MasonCentre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK.
Shruti GargDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Jonathan GreenDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Mark H JohnsonCentre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK.
Emily J H JonesCentre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, London, WC1E 7HX, UK. e.jones@bbk.ac.uk.ORCID 0000-0001-5747-9540
STAARS and EDEN Teams
Birkbeck, University of London · GBUniversity of Cambridge · GBUniversity of Manchester · GBMRC Cognition and Brain Sciences Unit · GB

Funding

Medical Research Council G0401546Medical Research Council MR/T003057/1
6 · The paper itself

Abstract

backgroundSensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies.

methodsIn this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD.

resultsIn typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits.

conclusionsThese findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

Indexed as

Auditory PerceptionAutism Spectrum DisorderNeurofibromatosis 1HumansInfantLongitudinal StudiesProspective StudiesAuditory processingAutism spectrum disorderChange detectionEEGHabituationNeurofibromatosis type 1

Identifiers

PMID34049498
PMCPMC8161667
OpenAlexW3158059110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.